Prevalence of Pulmonary Embolism in ICU

Completed

• Conditions: Pulmonary Embolism; Deep Venous Thrombosis

• Registration Number: NCT01457963
• Lead Sponsor: University Hospital, Grenoble

Brief Summary

The primary objective of this study was to estimate the prevalence of PE among consecutive ICU patients receiving MV who required thoracic computed tomography (CT) with contrast agent injection, regardless of whether PE was suspected clinically. The secondary objectives were to assess the association between PE and DVT, to identify risk factors for VTE, and to determine the outcome of VTE.

Detailed Description

Background: Pulmonary embolism (PE) produces nonspecific or minimal symptoms in mechanically ventilated (MV) patients, leading to underdiagnosis. We estimated the prevalence of PE and associations with deep vein thrombosis (DVT) among MV patients.

Methods: Consecutive MV patients who required thoracic computed tomography (CT) in a single ICU. Compression ultrasound of the four limbs was performed within 48 hours of inclusion. Curative anticoagulation therapy was given immediately after PE diagnosis.

Study Timeline

• Study Start: 2009-12
• Primary Completion: 2011-04
• Study Completion: 2011-04
• Status Verified: 2011-10
• Study First Submitted: 2011-10-20
• Study First Submitted QC: 2011-10-21
• Last Update Submitted: 2011-10-21
• Study First Posted: 2011-10-24
• Last Update Posted: 2011-10-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 176

Inclusion Criteria

• all patients requiring invasive MV and thoracic contrast-enhanced CT for any reason

Exclusion Criteria

• a diagnosis of PE before ICU admission,
• allergy to contrast agents,
• and age younger than 18 years.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Find a pulmonary embolism on the CT scan	CT scan at the day of inclusion	TO estimate the prevalence of PE among consecutive ICU patients receiving MV who required thoracic computed tomography (CT) with contrast agent injection, regardless of whether PE was suspected clinically.

Secondary Outcome Measures

Name	Time	Method
To find thrombus on compression ultrasound (CUS) of the four limbs	CUS within 48 hours after the CT scan

Trial Locations

Locations (1)

University hospital of grenoble; 🇫🇷 Grenoble, France