Brain Function and Perfusion in Patients With Heart Failure

• Conditions: Heart Failure; Dilated Cardiomyopathy; Perfusion; Cognitive Impairment; Cerebral Hypoperfusion

• Registration Number: NCT01756014
• Lead Sponsor: University Medical Center Groningen

Brief Summary

The investigators will evaluate the determinants of cerebral impairment in patients with non-ischemic heart failure compared to controls, and its relation to cognitive function. They hypothesize that patients with heart failure have impaired brain perfusion and hemodynamic factors are associated with cognitive dysfunction.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-01
• Status Verified: 2012-12
• Primary Completion: 2012-12
• Study First Submitted: 2012-12-19
• Study First Submitted QC: 2012-12-21
• Last Update Submitted: 2012-12-21
• Study First Posted: 2012-12-24
• Last Update Posted: 2012-12-24

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Determinants of cerebral impairment	Baseline	Determinants of cerebral impairment in patients with heart failure compared to controls, where cerebral impairment is defined as decreased cognitive function and cerebral hypoperfusion

Secondary Outcome Measures

Name	Time	Method
Prevalence of cognitive impairment	Baseline	Prevalence of cognitive impairment in patients with heart failure
Relation of cognitive impairment with local perfusion	Baseline	Relation of cognitive impairment with perfusion of carotid artery territory and basilar artery territory
Relation of cognitive impairment with the severity of heart failure	Baseline	Relation of cognitive impairment with the severity of heart failure
Relation of cognitive impairment with cardiac output	Baseline	Relation of cognitive impairment with cardiac output
Relation of cognitive impairment with the severity of congestion	Baseline	Relation of cognitive impairment with the severity of congestion
Relation of cognitive impairment with the decrease in cerebral perfusion	Baseline	Relation of cognitive impairment with the decrease in cerebral perfusion
The difference of cognitive domains in above relations	Baseline	The difference of cognitive domains in above relations

Trial Locations

Locations (1)

University Medical Centre Groningen; 🇳🇱 Groningen, Netherlands