Association of serum uric acid levels with post spinal hypotension during caesarean delivery an observational study in parturients with and without preeclampsia
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 190
- 试验地点
- 1
- 主要终点
- To study the association between hyperuricemia and the incidence of post spinal hypotension in parturients with and without pre-eclampsia undergoing emergency caesarean section under subarachnoid blockade
研究概览
简要总结
Uric acid is the final metabolite of purine metabolism and is mainly excreted by kidneys and intestine.
Uterine contractions during labour causing repeated ischemia and reperfusion can lead to rise in production of reactive oxygen species and
increase serum uric acid levels.
Pre-eclampsia is commonly associated with elevated serum uric acid (UA) levels, which is mainly thought to be due to renal impairment and
breakdown of purines from maternal, foetal, and placental tissues. Raised uric acid levels is considered a marker of hypertension, also it is
related to lesser use of vasopressors following spinal anaesthesia
.
There are studies that have established a positive correlation between hyperuricemia and decreased fall in blood pressure following spinal
anaesthesia in pre-eclamptic patients.
This study aims to evaluate the relationship between hyperuricemia and hypotension in parturients who have pre-eclampsia as well as
parturients who do not have pre-eclampsia.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 20.00 Year(s) 至 40.00 Year(s)（—）
- 性别
- Female
入选标准
- •Parturients undergoing emergency caesarean section under spinal anaesthesia.
排除标准
- •preexisting coagulation abnormalities hyperuricemia before pregnancy twin pregnancy abnormal placenta polyhydraminos oligohydraminos gestation less than 34weeks use of general anaesthesia and epidural anaesthesia height less than 150cm and more than 180cm contraindication for spinal anaesthesia eclampsia medical disorders like cardiac disease ,chronic hypertension, renal disease ,endocrine disease.
结局指标
主要结局
To study the association between hyperuricemia and the incidence of post spinal hypotension in parturients with and without pre-eclampsia undergoing emergency caesarean section under subarachnoid blockade
时间窗: 1,3,5,10 minutes after subarachnoid block
次要结局
- To compare the need for supplemental uterotonic agents(after delivery of baby to end of surgery)
研究者
Dr Shamitha R
Rajarajeswari Medical College and Hospital