NCT01351142已完成不适用
Cytokines and Cognitive Decline in Alzheimer's Disease
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 133
- 试验地点
- 20
研究概览
简要总结
Amyloid plaques and neurofibrillary tangles are the 2 well-known etiopathological hallmarks of Alzheimer's disease (AD). Beside these 2 lesions, inflammation response is described in the brain of patients with AD.
The main objective of our study is to analyse the correlation between the value of plasma cytokines (interleukin 1, 6, TNFα and chemochine Rantes) and the rapidity of the cognitive decline in AD over a 2-year follow-up.
Secondary objectives include:
- the predictive value of the cytokines on the cognitive decline after 6 months and one year of follow-up., of the patients include 150 patients with AD (MMSE: 16-25)
- correlation between plasma cytokines levels and expression of the protein kinase PKR (involved in death cell) in blood mononuclear cells.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Alzheimer's disease (AD)patients
- •MMSE score: 16-25
- •Written informed consent
排除标准
- •AD patients with specific treatment for AD before inclusion MMSE score under 16 or over 25 at inclusion
- •patients with anti-inflammatory drugs (non steroids or corticosteroids) or immunosuppressive agents
- •Patients with acute disease (infectious disease, rheumatologic disease) or chronic disease (malignancy, infectious, rheumatologic disease) that could interact with plasma cytokines level
- •Patients with a life threatening disease
研究者
研究点 (20)
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