Antagonistic Interaction CB1-paracetamol

Phase 1

Completed

• Conditions: Pain

• Registration Number: NCT00750347
• Lead Sponsor: University Hospital, Clermont-Ferrand

Brief Summary

Evaluation of an possible inhibiting effect of Rimonabant on the analgesic effect of Paracetamol in healthy volunteers

Detailed Description

Double Blind, cross-over, randomized and controlled versus placebo, study in healthy volunteers.

Study Timeline

• Study Start: 2008-09
• Study First Submitted: 2008-09-09
• Study First Submitted QC: 2008-09-09
• Study First Posted: 2008-09-10
• Primary Completion: 2008-10
• Study Completion: 2008-10
• Status Verified: 2011-01
• Last Update Submitted: 2011-01-18
• Last Update Posted: 2011-01-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• Healthy volunteers
• between 18 and 40 years old
• written consent given

Exclusion Criteria

• Rimonabant or paracetamol hypersensibility
• Excessive consumption of alcohol, tobacco, coffee, tea or toxicomania
• Concomitant medication
• Chronical diseases

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Pain's threshold with electrical stimulation (Pain Matcher). Pain's threshold with mechanical stimulation (electronical Von Frey).	during electrical stimulation

Secondary Outcome Measures

Name	Time	Method
Plasmatic concentration of paracetamol or his metabolite with or without Rimonabant	with or without rimonabant

Trial Locations

Locations (2)

CIC-CPC; 🇫🇷 Clermont-Ferrand, France

CHU Clermont-Ferrand; 🇫🇷 Clermont-Ferrand, France