Effect of High Altitude Exposure, Acclimatization and Re-exposure on Postural Control in Lowlanders
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 21
- 试验地点
- 1
- 主要终点
- Center of pressure path length measured by Wii-balance board
研究概览
简要总结
Prospective interventional trial in lowlanders evaluating the effect of acute exposure, acclimatization and re-exposure to high altitude on postural control
详细描述
Baseline measurements including the assessment of the center of pressure during 30s, the cerebral oxygen saturation and a sharpened Romberg test will be performed in Santiago de Chile, 520 m, over the course of 3 days. Participants will then travel by commercial airline (5 h flight) and by bus (3 h ride) to the base camp of the Atacama Large Millimeter/Submillimeter Array (ALMA) telescope station located at 2900 m near San Pedro de Atacama, northern Chile. Participants will stay there for the next 8 nights and they will be spend the days (6-8 h daily) at the telescope station at 5050 m while undergoing testing as described above at the first and the last day at 5050m. Daily transports from 2900 to 5050 m will be by car (1 h ride, one way). After the first 8 day altitude sojourn participants will return to the Santiago area (520 m) for a 6 day recovery period.
A second altitude sojourn with an identical schedule as the one described above and a final low altitude stay of 3 days will follow.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •born, raised and currently living <800m
- •No overnight stay at altitudes >1500 m 4 weeks before the study
排除标准
- •Previous altitude intolerance to altitude <3000 m
- •Pregnancy
- •Health impairment, which requires regular treatment
研究组 & 干预措施
Altitude exposure
Acute high altitude exposure followed by 8 day acclimatization and reexposure for 8 days after 6 days at low altitude
干预措施: altitude exposure (Other)
结局指标
主要结局
Center of pressure path length measured by Wii-balance board
时间窗: Low altitude sojourn at 520 m; first sojourn at 5050 m Day 2, 7; second sojourn at 5050 m Day 2, 7
Changes in center of pressure path length during the 2 sojourns at 5050 m and compared to lowland.
次要结局
- Cerebral tissue oxygen saturation measured by near infrared spectroscopy(Low altitude sojourn at 520 m; first sojourn at 5050 m Day 2, 7; second sojourn at 5050 m Day 2, 7)
- Postural stability measured by sharpened Romberg-test and heel-to-toe walk(Low altitude sojourn at 520 m; first sojourn at 5050 m Day 2, 7; second sojourn at 5050 m Day 2, 7)