Director of Research Division
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 350
- 试验地点
- 1
- 主要终点
- Success Rate
研究概览
简要总结
- Gastric eradication has no effective on oral H. pylori infection.
- Treatment of oral infection increase success rate of eradication on stomach infection.
详细描述
Objective
The present study was aimed to explore the relationship of Helicobacter pylori(H. pylori) of the oral cavity with the success rate eradication of gastric H. pylori infection.
Study Design and Setting: 202 symptomatic and 148 asymptomatic individuals were recruited and tested using Saliva H. pylori antigen tests (HPS), H. pylori flagellin (HPF), the urea breathe test (UBT) and the polymerase chain reaction (PCR) test. Test subjects also received various treatments.
We collected data of HPS, HPF , PCR and UBT before treatment on 202 symptomatic patients and 148 asymptomatic individual groups. After drug treatment, we run HPS, HPF, PCR and UBT tests. If the tests of HPS, HPF and PCR show negative that indicate success of oral H.pylori eradication. If the test of UBT show negative that indicate success of stomach H.pyloi eradication. We also compare the suceess rate of eradication on stomach infection with and without oral H. pylori infection.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •patients with gastrointestinal complaints
排除标准
- •patients who had taken any antibiotics and/or proton pump inhibitors within four weeks prior to sample collection
研究组 & 干预措施
Amoxicillin and Tetracyclines
drug treatment
干预措施: Amoxicillin and Tetracyclines (Drug)
Mouth washing
Mouth washing
干预措施: Mouth washing (Drug)
结局指标
主要结局
Success Rate
时间窗: 12 months
次要结局
- Diagnostic(6 months)
研究者
K C Yee
Director of Research Division
Ameritek USA