The evaluation of effectiveness of a topical formulation of linseed oil in patients with knee osteoarthritis
- Conditions
- knee osteoarthritis.Gonarthrosis
- Registration Number
- IRCT2017082011341N9
- Lead Sponsor
- Vice chancellor for research,Fasa University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 94
the age between 35-70 years;at least having pain in one knee for past 3 months;recognition of osteoarthritis by the doctor according to American college of rheumatology classification criteria; recognition of grade I to III osteoarthritis by the doctor according to Kellegren-Lawrence(K-L)grading scale;absence of any congenital abnormality in lower extremity;written informed consent for inclusion.
sensitivity and allergy to linseed or diclofenac gel or acetaminophen;skin disease in knee;patients with secondary osteoarthritis due to other bone joint disorders like rheumatoid arthritis, gout, infected arthritis, metabolic arthritis, traumatic arthritis; joint replacement; oral and topical use of corticostreoid in past 14 days;knee corticosteroid or hyaluronic acid injection in the past 90 days; other articular corticosteroid or hyaluronic acid injection in the past 1 month;topical or oral usage of painkillers in past 3 days;concomitant use of glucosamin or chondroitin sulfate;pregnancy and lactation; alcohol or drug addiction; disability to cooperate in filling the forms (cognitive or language disorder); patients with active peptic ulcer diseases and inflammatory bowl disease(IBD);BMI = 35 kg/m^2;physical modality in knee joint in past 2 weeks like physical therapy,acupuncture and Transcutaneous Electrical Nerve Stimulator (TENS).
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Visual analogue scale. Timepoint: At the beginning of intervention,after2 weeks then after 4 weeks from the beginning of intervention. Method of measurement: Asking the patients.
- Secondary Outcome Measures
Name Time Method Function in daily living (ADL). Timepoint: At the beginning of intervention,after 2 weeks then 4 weeks afterthe beginning of intervention. Method of measurement: KOOS questionnaire.;Other Symptoms. Timepoint: At the beginning of intervention,after 2 weeks then 4 weeks afterthe beginning of intervention. Method of measurement: KOOS questionnaire.;Pain. Timepoint: At the beginning of intervention,after 2 weeks then 4 weeks afterthe beginning of intervention. Method of measurement: KOOS questionnaire.;Function in sport and recreation(Sport/Rec). Timepoint: At the beginning of intervention,after 2 weeks then 4 weeks afterthe beginning of intervention. Method of measurement: KOOS questionnaire.;Knee related quality of life(QOL). Timepoint: At the beginning of intervention,after 2 weeks then 4 weeks afterthe beginning of intervention. Method of measurement: KOOS questionnaire.