Intravascular Volume Assessment Using Ultrasonography in Pediatrics Renal Transplant: A Prospective Cohort Study

• Conditions: Chronic Kidney Failure
• Interventions: Device: ultrasonography

• Registration Number: NCT04008953
• Lead Sponsor: Fatma Alzahraa Mohamed Ibrahim Hassan Haggag

Brief Summary

This study is designed for volume assessment in pediatrics during major surgery using non-invasive tools as ultrasonography without the need of invasive techniques avoiding its complications and as a guide for fluid therapy needed for maintaining adequate hemodynamics

Detailed Description

Intravascular volume assessment during surgery is important for maintaining adequate hemodynamics. Methods approved for volume assessment include the use of echocardiography to measure left ventricular end diastolic area (LVEDA), central venous pressure (CVP) and pulmonary artery diastolic pressure (PAD). LVEDA is considered the good predictor for volume status assessment. CVP and PAD are invasive can potentially subject the patient to complications. Recently study performed an ultrasound assessment of the internal jugular vein (IJV) as a useful means of volume status assessment intraoperative under general anesthesia. In the pediatric population, only few studies are carried out to assess the use of ultrasound for intravascular volume assessment. This study will evaluate use of Ultrasonography of IJV in volume assessment in pediatrics will undergo renal transplant surgery and correlate IJV diameter, cross sectional area to CVP and LVEDA.

Study Timeline

• Status Verified: 2019-07
• Study Start: 2019-07
• Study First Submitted: 2019-07-02
• Study First Submitted QC: 2019-07-02
• Study First Posted: 2019-07-05
• Last Update Submitted: 2019-07-07
• Last Update Posted: 2019-07-09
• Primary Completion: 2019-10
• Study Completion: 2019-11

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

• Pediatric patients with end stage renal disease
• Weight between: 12 to 30 kg

Exclusion Criteria

• Infection at the site of CVP or generalized infection.
• IJV thrombosis

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Sixteen patients having end stage renal disease	ultrasonography	Intravascular volume assessment in 16 pediatric patients under going renal transplant surgery using ultrasonography, CVP and echocardiography

Primary Outcome Measures

Name	Time	Method
Internal jugular vein diameter, cross sectional area and left ventricular end-diastolic area	3months	Correlation of IJV diameter and cross sectional area to LVEDA.

Secondary Outcome Measures

Name	Time	Method
Internal jugular vein diameter, cross sectional area and central venous pressure	3months	Correlation of IJV diameter and cross sectional area to CVP.