Diabetes in Asians at Risk in Youth
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 3,000
- 主要终点
- Diagnosis of diabetes
研究概览
简要总结
This observational study aims to develop novel contemporary risk factor tools for detecting young onset diabetes (under 40y) in young Asians in Singapore. The investigators aim to recruit 3000 people not currently known to have diabetes, selected across age and Body Mass Index categories, and perform formal diagnostic tests for diabetes (oral glucose tolerance test and HbA1c). The participants will also undergo continuous glucose monitoring sensor, keep a food diary, and undergo body composition analysis using bioimpedance analysis, handgrip measurements for muscle strength, and sociobehavioural profiling through download of a curated list of social media interactions. The participants will also have a blood sample retrieved and stored for subsequent comparison between people with normal glucose versus abnormal glucose levels. The whole group will also have another blood sample stored for whole gene analysis.
详细描述
Overarching aim: To improve the case detection rate of T2D in young Singaporeans adults aged 21-40y.
Specific Aim 1: To conduct a case-finding study for T2D and prediabetes through age- and BMI-stratified sampling in a contemporary population of young Singaporean adults aged 21-40y.
Specific Aim 2: To identify novel risk factors and develop a composite score to improve the detection rate for Asian YOD and prediabetes. These include non-traditional predictors such as glucometrics from continuous glucose monitoring (CGM), body composition measures, and socio-behavioural analyses.
Specific Aim 3: To identify the contribution of genomic differences to the risk of Asian Young Onset Diabetes
To fulfil Aim 1 within the first 1 to 2 years, the investigators plan to perform island-wide screening for diabetes or prediabetes amongst people aged 21-40y (n=3000). Recruitment will be stratified firstly by age categories (21-25y, 25-30y, 30-35y, 35-40y), aiming for n=750 per age category, followed by BMI categories of normal, overweight or obese by Asian thresholds (<23kgm2, 23-27.5kg/m2 and >=27.5kg/m2) within each age group. Participants will be recruited through online and print media including social media advertisements, word of mouth and /or referrals. A study poster advert will be posted online and in print, which will then direct participants to a webpage www.thdiary.sg which will explain the study design further and eligibility requirements and additional study details. The partiipants can proceed to register themselves via FORMSG on this webpage and if they meet the criteria they will be directed to CALSG to book an appointment with the study team.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 21 Years 至 39 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Asian/Part Asian ethnicity living in Singapore, not known to have diabetes
排除标准
- •Pregnancy women
- •Non-Asian ethnicity
- •On active cancer/steroid therapy
- •Haemoglobinopathies or haemolytic anaemia
- •Previous bariatric surgery
- •Previous partial/total pancreatectomy
研究组 & 干预措施
Singaporeans of Asian ethnicity under 40 years
Not previously known to have diabetes
干预措施: Oral glucose tolerance test and HbA1c (Diagnostic Test)
Singaporeans of Asian ethnicity under 40 years
Not previously known to have diabetes
干预措施: Anthropometric measurements (Other)
Singaporeans of Asian ethnicity under 40 years
Not previously known to have diabetes
干预措施: Body impedance Analysis (Diagnostic Test)
Singaporeans of Asian ethnicity under 40 years
Not previously known to have diabetes
干预措施: Handgrip measurement (Diagnostic Test)
Singaporeans of Asian ethnicity under 40 years
Not previously known to have diabetes
干预措施: Continuous glucose monitoring (Diagnostic Test)
Singaporeans of Asian ethnicity under 40 years
Not previously known to have diabetes
干预措施: Food diary recording over days 2 and 3 of continuous glucose monitoring (Other)
Singaporeans of Asian ethnicity under 40 years
Not previously known to have diabetes
干预措施: Survey (Other)
Singaporeans of Asian ethnicity under 40 years
Not previously known to have diabetes
干预措施: Skin reaction information (Other)
Singaporeans of Asian ethnicity under 40 years
Not previously known to have diabetes
干预措施: Download of social media data (Other)
Singaporeans of Asian ethnicity under 40 years
Not previously known to have diabetes
干预措施: Whole genome sequencing (Diagnostic Test)
结局指标
主要结局
Diagnosis of diabetes
时间窗: Baseline
Fasting glucose \>/=7mmol/l or 2-hour glucose \>/=11.1 mmol/l on oral glucose tolerance test or HbA1c \>/=7%.
次要结局
- Diagnosis of pre-diabetes(Baseline)