Adolescent Inpatients With Anorexia Nervosa: Changes in Heart Rate Variability, Body Warmth and Eating Disorder Features - a Prospective Controlled Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Anorexia Nervosa
- Sponsor
- ARCIM Institute Academic Research in Complementary and Integrative Medicine
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- Change in Drive for Thinness
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
A study to assess changes in mental and physical symptoms in adolescent inpatients with anorexia nervosa, a severe eating disorder.
Detailed Description
This is a prospective controlled trial to assess changes in psycho-physiological parameters, including eating disorder features (drive for thinness, body dissatisfaction) and comorbid symptoms such as anxiety, depression and quality of life as well as heart rate variability, body warmth and BMI in adolescent inpatients with anorexia nervosa. Parameters were assessed at admission, six weeks after admission and three months thereafter and compared to reference values of healthy controls.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age 11-18 years
- •Restrictive subtype of adolescent AN
- •Fulfilling the AN diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV and V)
- •Admitted to the Filderklinik for inpatient treatment
Exclusion Criteria
- •Patients diagnosed with the binge-purge subtype of adolescent AN or with other eating disorders
- •Healthy controls: BMI beyond the defined norm for their age group
- •Healthy controls: acute or chronic disorders including psychiatric disorders, heart defects, cardiac arrhythmia, other disorders requiring medication
Outcomes
Primary Outcomes
Change in Drive for Thinness
Time Frame: At admission (timepoint 1, t1), six weeks after admission (t2), and three months after t2 (t3)
Assessed with the 7-item subscale Drive for Thinness of the self-reporting Eating Disorder Inventory-2 at admission to the hospital (t1), six weeks after admission (t2) and three months after t2 (t3)
Change in Body Dissatisfaction
Time Frame: At admission (t1), six weeks after admission (t2), and three months after t2 (t3)
Assessed with the 9-item subscale Body Dissatisfaction of the self-reporting Eating Disorder Inventory-2 at admission to the hospital (t1), six weeks after admission (t2) and three months after t2 (t3)
Secondary Outcomes
- Weight gain(At admission (t1), six weeks after admission (t2), and three months after t2 (t3))
- Heart rate variability: SDNN(At admission (t1), six weeks after admission (t2), and three months after t2 (t3))
- SF-12 physical(At admission (t1), six weeks after admission (t2), and three months after t2 (t3))
- Anxiety(At admission (t1), six weeks after admission (t2), and three months after t2 (t3))
- SF-12 global(At admission (t1), six weeks after admission (t2), and three months after t2 (t3))
- Depression(At admission (t1), six weeks after admission (t2), and three months after t2 (t3))
- Body warmth(At admission (t1), six weeks after admission (t2), and three months after t2 (t3))
- SF-12 mental(At admission (t1), six weeks after admission (t2), and three months after t2 (t3))
- Heart rate(At admission (t1), six weeks after admission (t2), and three months after t2 (t3))