Youth Depression Alleviation: A randomised controlled trial of omega-3 fatty acids (fish oil) for major depressive disorder in young people (YoDA-F)

Orygen Youth Health Research Centre0 个研究点目标入组 233 人开始时间: 2013年12月11日最近更新: 2023年11月6日

试验速览

暂无简介。

•1) Aged 15-25 years help seeking for psychological distress.
•2) A score between 11 and 20 on the QIDS-A17-C at first contact with the service AND after 1 week (plus 1-5 days if the client is unable to attend earlier) at the second assessment, or at 2 subsequent (weekly) follow-up assessments.
•3) A diagnosis of major depressive disorder using the Structured Clinical Interview for DSM-IV Axis I Disorders, patient version (SCID-I/P).
•4) Written informed consent (for individuals under 18, written informed consent of at least one parent or a guardian is required).

•1) Lifetime diagnosis or history of treatment for psychotic disorder or bipolar disorder or substance dependence (assessed with a brief, self-developed checklist).
•2) History of treatment with an antidepressant (more than four weeks during the last 12 months, upon review of medical history).
•3) Acute suicidal behaviour as assessed by a score of 6 on the Comprehensive Assessment of At Risk Mental States (CAARMS; item 7.3) or aggressive behaviour (score of 6 on CAARMS item 5.4).
•4) Depression secondary to a medical condition.
•5) IQ<70 as per medical history review.
•6) Pregnancy or lactation.
•7) Laboratory values more than 15% outside the normal range for bleeding parameters.
•8) Individuals who are taking omega-3 supplements or psychotropic medication, currently or within 8 weeks of being included in the trial, for more than 1 week continuously.
•9) Known allergy to omega-3s or any ingredients in the investigational product.

发起方

Orygen Youth Health Research Centre