Treatment of Dysglycemia Using Sitagliptin in Adolescents With Cystic Fibrosis
- Registration Number
- NCT01721382
- Lead Sponsor
- Nemours Children's Clinic
- Brief Summary
This pilot study will be conducted in adolescents with cystic fibrosis (CF) without diabetes but with abnormal glucose tolerance, and will assess the effects of sitagliptin on glucose regulation. An oral glucose tolerance test (OGTT) and a mixed meal tolerance test (MMTT), will be performed at baseline and again \~4 weeks after treatment with study drug. We will also look at blood sugars throughout the day using a continuous glucose monitor (CGM) before each time the MMTT/OGTT are performed. Several hormones that may affect the way the body regulates blood sugars will be measured in blood when the OGTT and MMTT are done. We will assess the effect this medicine has on blood sugars (using CGM) and the effect the medicine has on the hormones measured during the OGTT and MMTT.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 6
- Patients with CF between 13 and <21 yrs old
- Known impaired or indeterminate glucose tolerance (based on a prior OGTT)
- No history of CFRD
- Insulin use in the last two months
- Acute pulmonary exacerbation / oral corticosteroid use in the last 6 weeks
- History of pancreatitis in the last 12 months
- Skin rashes or conditions that may affect CGM placement and wear
- Pregnancy or intent on becoming pregnant
- Patients on growth hormone therapy
- Renal insufficiency with creatinine clearance <50 ml/min (based on Schwartz formula)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Sitagliptin Sitagliptin Treatment with sitagliptin
- Primary Outcome Measures
Name Time Method Response to sitagliptin Change from baseline to ~4 weeks of study drug Change in incretin (glucagon like peptide 1; glucose-dependent insulinotropic polypeptide) concentrations in response to study drug.
- Secondary Outcome Measures
Name Time Method Beta-cell function Change from baseline to ~4 weeks of study drug Beta-cell function will be measured using mixed meal tolerance tests (MMTT) and oral glucose tolerance tests (OGTT), assessing maximum concentration and area under the curve (AUC) of glucose, insulin and c-peptide for both OGTT and MMTT.
Continuous glucose monitoring (CGM) change from baseline to ~4 weeks of study drug Baseline and post-treatment changes in glycemic variability using CGM, including mean amplitude of glycemic excursion (MAGE), peak post-prandial blood sugars, and glucose area under the curve.
Trial Locations
- Locations (1)
Nemours Children's Clinic
🇺🇸Jacksonville, Florida, United States