Post-marketing Observational Study in Subjects With Rheumatoid Arthritis
- Conditions
- Rheumatoid Arthritis
- Interventions
- Biological: adalimumab
- Registration Number
- NCT00234884
- Lead Sponsor
- Abbott
- Brief Summary
The purpose of this observational study was to observe and assess the long term use, safety, and effectiveness of adalimumab in a normal clinical setting.
- Detailed Description
This was a multicenter, uncontrolled, 5-year observational study of adalimumab in the treatment of patients with rheumatoid arthritis (RA) who had received adalimumab for at least 3 months in NCT00448383 (Study M02-497), an interventional study that ended when adalimumab became commercially available for the treatment of RA. Participants had to have been receiving ongoing adalimumab treatment at the time NCT00448383 (Study M02-497) ended and been prescribed commercial adalimumab, and could have received commercial adalimumab for up to 1 year afterward prior to enrollment in NCT00234884 (Study M03-634).
Physician investigators were encouraged to treat participants as they would any other patient with RA in their routine clinical practice, and were free to determine the appropriate therapy for each patient. Concomitant treatment with disease-modifying antirheumatic drugs (DMARDs), including methotrexate, could be continued while receiving adalimumab. If treatment with adalimumab was permanently discontinued for any reason, participants were discontinued from the study and the reason was recorded. Investigators were asked to record adverse events up to 3 months after last administration of adalimumab.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 3435
- Participants with ongoing adalimumab treatment who completed at least Month 3 (Visit 5) of NCT00448383 (Study M02-497) and who had subsequently been prescribed adalimumab according to the Summary of Product Characteristics (SmPC).
- Participants must have been willing to consent to data being collected and provided to Abbott.
· Participants with contraindications according to the SmPC.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Adalimumab adalimumab RA patients in treatment with commercial adalimumab
- Primary Outcome Measures
Name Time Method Disease Activity Score in 28 Joints (DAS28) Based on Erythrocyte Sedimentation Rate (ESR) Baseline, Months 12, 24, 36, 48, and 60, and Last Observed Value DAS28 is a composite measure of disease activity in patients with rheumatoid arthritis. It is calculated on the basis of tender and swollen joint counts (each assessed in 28 joints), the patient's ESR, and the patient's subjective assessment of disease activity (assessed using a 100-mm visual analog scale). A DAS28 less than 3.2 indicates low disease activity and a DAS28 greater than 5.1 indicates high disease activity; there is no absolute range of scores due to inter-patient variability in ESR.
American College of Rheumatology 20% (ACR20) Response Rate Baseline, Months 12, 24, 36, 48, and 60, and Last Observed Value ACR20 response is a 20% or better improvement from Baseline in tender joint count, swollen joint count, and at least 3 of the following 5 parameters: patient's assessment of pain, patient's global assessment of disease activity, physician's global assessment of disease activity, Health Assessment Questionnaire Disability Index (HAQ-DI), and C-reactive protein. Response was calculated based on values at Baseline of NCT00448383 (Study M02-497).
American College of Rheumatology 50% (ACR50) Response Rate Baseline, Months 12, 24, 36, 48, and 60, and Last Observed Value ACR50 response is a 50% or better improvement from Baseline in tender joint count, swollen joint count, and at least 3 of the following 5 parameters: patient's assessment of pain, patient's global assessment of disease activity, physician's global assessment of disease activity, Health Assessment Questionnaire Disability Index (HAQ-DI), and C-reactive protein. Response was calculated based on values at Baseline of NCT00448383 (Study M02-497).
American College of Rheumatology 70% (ACR70) Response Rate Baseline, Months 12, 24, 36, 48, and 60, and Last Observed Value ACR70 response is a 70% or better improvement from Baseline in tender joint count, swollen joint count, and at least 3 of the following 5 parameters: patient's assessment of pain, patient's global assessment of disease activity, physician's global assessment of disease activity, Health Assessment Questionnaire Disability Index (HAQ-DI), and C-reactive protein. Response was calculated based on values at Baseline of NCT00448383 (Study M02-497).
Change From Baseline in the Health Assessment Questionnaire Disability Index (HAQ-DI) Baseline, Months 12, 24, 36, 48, and 60, and Last Observed Value HAQ-DI is a composite measure of physical function calculated on the basis of 20 questions in 8 domains (dressing, arising, eating, walking, hygiene, reach, grip, and common activities), each evaluated on a 4-point scale ranging from 0 (without any difficulty) to 3 (unable to do). HAQ-DI score is the sum of worst scores in each domain divided by the number of domains answered, and ranges from 0 (no difficulty) to 3 (unable to do). A mean change of -0.22 is considered the minimum clinically important change. Mean change in HAQ-DI was calculated from Baseline of NCT00448383 (Study M02-497).
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (311)
Site Ref # / Investigator 26425
🇬🇷Patras, Greece
Site Ref # / Investigator 49810
🇧🇪Hasselt, Belgium
Site Ref # / Investigator 49814
🇧🇪Hasselt, Belgium
Site Ref # / Investigator 49787
🇧🇪Oostende, Belgium
Site Ref # / Investigator 49772
🇧🇪Brussels, Belgium
Site Ref # / Investigator 49781
🇧🇪Hamme, Belgium
Site Ref # / Investigator 49775
🇧🇪Lier, Belgium
Site Ref # / Investigator 49798
🇧🇪Braine-l'Alleud, Belgium
Site Ref # / Investigator 49773
🇧🇪Bruges, Belgium
Site Ref # / Investigator 49763
🇧🇪Brussels, Belgium
Site Ref # / Investigator 49795
🇧🇪Destelbergen, Belgium
Site Ref # / Investigator 49776
🇧🇪Genk, Belgium
Site Ref # / Investigator 49768
🇧🇪Edegem, Belgium
Site Ref # / Investigator 49771
🇧🇪Mechelen, Belgium
Site Ref # / Investigator 49770
🇧🇪Namur, Belgium
Site Ref # / Investigator 49783
🇧🇪Namur, Belgium
Site Ref # / Investigator 49797
🇧🇪Nukerke, Belgium
Site Ref # / Investigator 49801
🇧🇪La Louviere, Belgium
Site Ref # / Investigator 49815
🇧🇪Mechelen, Belgium
Site Ref # / Investigator 49796
🇧🇪Merksem, Belgium
Site Ref # / Investigator 49891
🇧🇪Montignies-sur-Sambre, Belgium
Site Ref # / Investigator 49793
🇧🇪Sijsele, Belgium
Site Ref # / Investigator 49805
🇧🇪Sint-Niklaas, Belgium
Site Ref # / Investigator 49827
🇳🇱Utrecht, Netherlands
Site Ref # / Investigator 49835
🇳🇱Vlissingen, Netherlands
Site Ref # / Investigator 49566
🇬🇷Thessaloniki, Greece
Site Ref # / Investigator 49569
🇬🇷Thessaloniki, Greece
Site Ref # / Investigator 49518
🇦🇹Innsbruck, Austria
Site Ref # / Investigator 49746
🇦🇹Klagenfurt, Austria
Site Ref # / Investigator 4961
🇦🇹Vienna, Austria
Site Ref # / Investigator 26427
🇵🇹Ponte de Lima, Portugal
Site Ref # / Investigator 49523
🇦🇹Oberpullendorf, Austria
Site Ref # / Investigator 49794
🇧🇪Aalst, Belgium
Site Ref # / Investigator 49521
🇦🇹Graz, Austria
Site Ref # / Investigator 49817
🇧🇪Antwerp, Belgium
Site Ref # / Investigator 49806
🇧🇪Bonheiden, Belgium
Site Ref # / Investigator 49516
🇦🇹Linz, Austria
Site Ref # / Investigator 49519
🇦🇹Stockerau, Austria
Site Ref # / Investigator 49808
🇧🇪Belsele, Belgium
Site Ref # / Investigator 49520
🇦🇹Vienna, Austria
Site Ref # / Investigator 49809
🇧🇪Bonheiden, Belgium
Site Ref # / Investigator 49811
🇧🇪Brussels, Belgium
Site Ref # / Investigator 49766
🇧🇪Gosselies, Belgium
Site Ref # / Investigator 49748
🇦🇹Laab im Walde, Austria
Site Ref # / Investigator 49745
🇦🇹St. Poelten, Austria
Site Ref # / Investigator 49788
🇧🇪Assebroek, Belgium
Site Ref # / Investigator 49774
🇧🇪Brussels, Belgium
Site Ref # / Investigator 49791
🇧🇪Brussels, Belgium
Site Ref # / Investigator 49762
🇧🇪Brussels, Belgium
Site Ref # / Investigator 49780
🇧🇪Chimay, Belgium
Site Ref # / Investigator 49813
🇧🇪Genk, Belgium
Site Ref # / Investigator 26424
🇧🇪Ghent, Belgium
Site Ref # / Investigator 49777
🇧🇪Kortrijk, Belgium
Site Ref # / Investigator 49767
🇧🇪La Louviere, Belgium
Site Ref # / Investigator 49789
🇧🇪Liege, Belgium
Site Ref # / Investigator 49350
🇫🇷Angers, France
Site Ref # / Investigator 49816
🇧🇪Leuven, Belgium
Site Ref # / Investigator 49785
🇧🇪Mons, Belgium
Site Ref # / Investigator 49332
🇫🇷Aix Les Bains, France
Site Ref # / Investigator 49615
🇫🇷Aix en Provence, France
Site Ref # / Investigator 49621
🇫🇷Berck, France
Site Ref # / Investigator 49468
🇩🇪Hamburg, Germany
Site Ref # / Investigator 49544
🇩🇪Herrsching, Germany
Site Ref # / Investigator 49483
🇩🇪Duisburg, Germany
Site Ref # / Investigator 49610
🇫🇷Gonesse, France
Site Ref # / Investigator 49628
🇫🇷Cherbourg, France
Site Ref # / Investigator 49579
🇩🇪Erlangen, Germany
Site Ref # / Investigator 49624
🇫🇷Colombes, France
Site Ref # / Investigator 49481
🇩🇪Essen, Germany
Site Ref # / Investigator 49362
🇫🇷Marseilles, France
Site Ref # / Investigator 49474
🇩🇪Dresden, Germany
Site Ref # / Investigator 49353
🇫🇷Nice, France
Site Ref # / Investigator 49326
🇫🇷Paris, France
Site Ref # / Investigator 49433
🇩🇪Berlin, Germany
Site Ref # / Investigator 49551
🇩🇪Cologne, Germany
Site Ref # / Investigator 49454
🇩🇪Berlin, Germany
Site Ref # / Investigator 49705
🇩🇪Berlin, Germany
Site Ref # / Investigator 49573
🇩🇪Aachen, Germany
Site Ref # / Investigator 49568
🇬🇷Athens, Greece
Site Ref # / Investigator 49554
🇬🇷Athens, Greece
Site Ref # / Investigator 49585
🇬🇷Athens, Greece
Site Ref # / Investigator 49581
🇬🇷Larisa, Greece
Site Ref # / Investigator 49558
🇩🇪Schlangenbad, Germany
Site Ref # / Investigator 49704
🇩🇪Marl, Germany
Site Ref # / Investigator 49475
🇩🇪Erlangen, Germany
Site Ref # / Investigator 49548
🇩🇪Hildesheim, Germany
Site Ref # / Investigator 49422
🇩🇪Halle, Germany
Site Ref # / Investigator 49431
🇩🇪Leipzig, Germany
Site Ref # / Investigator 49440
🇩🇪Muenster, Germany
Site Ref # / Investigator 49587
🇩🇪Hofheim, Germany
Site Ref # / Investigator 49711
🇩🇪Freiburg, Germany
Site Ref # / Investigator 49556
🇩🇪Fuerth, Germany
Site Ref # / Investigator 49557
🇩🇪Ludwigshafen, Germany
Site Ref # / Investigator 49547
🇩🇪Moenchengladbach, Germany
Site Ref # / Investigator 49450
🇩🇪Munich, Germany
Site Ref # / Investigator 49424
🇩🇪Ludwigsburg, Germany
Site Ref # / Investigator 49447
🇩🇪Jena, Germany
Site Ref # / Investigator 49549
🇩🇪Ratingen, Germany
Site Ref # / Investigator 49580
🇬🇷Athens, Greece
Site Ref # / Investigator 49565
🇬🇷Athens, Greece
Site Ref # / Investigator 49460
🇩🇪Villingen, Germany
Site Ref # / Investigator 49456
🇩🇪Vogelsang-Gommern, Germany
Site Ref # / Investigator 49708
🇩🇪Rostock, Germany
Site Ref # / Investigator 49564
🇬🇷Heraklion, Greece
Site Ref # / Investigator 49449
🇩🇪Wuppertal, Germany
Site Ref # / Investigator 49437
🇩🇪Stuttgart, Germany
Site Ref # / Investigator 49584
🇬🇷Athens, Greece
Site Ref # / Investigator 49567
🇬🇷Ioannina, Greece
Site Ref # / Investigator 49593
🇮🇹Bologna, Italy
Site Ref # / Investigator 50052
🇮🇹Milano, Italy
Site Ref # / Investigator 50057
🇮🇹Rome, Italy
Site Ref # / Investigator 49545
🇩🇪Wuerzburg, Germany
Site Ref # / Investigator 49553
🇬🇷Thessaloniki, Greece
Site Ref # / Investigator 49983
🇮🇹Bari, Italy
Site Ref # / Investigator 49591
🇮🇹Arenzano (GE), Italy
Site Ref # / Investigator 49990
🇮🇹Acqui Terme (AL), Italy
Site Ref # / Investigator 49987
🇮🇹Florence, Italy
Site Ref # / Investigator 49976
🇮🇹Milano, Italy
Site Ref # / Investigator 49822
🇮🇹Prato, Italy
Site Ref # / Investigator 49515
🇵🇹Lisboa, Portugal
Site Ref # / Investigator 49512
🇵🇹Ponta Delgada-Acores, Portugal
Site Ref # / Investigator 49830
🇳🇱Rotterdam, Netherlands
Site Ref # / Investigator 49662
🇪🇸Asturias, Spain
Site Ref # / Investigator 49903
🇳🇱Venlo, Netherlands
Site Ref # / Investigator 49946
🇮🇹Reggio Emilia, Italy
Site Ref # / Investigator 49646
🇪🇸Barcelona, Spain
Site Ref # / Investigator 49950
🇮🇹Rome, Italy
Site Ref # / Investigator 49991
🇮🇹San Cesario Lecce, Italy
Site Ref # / Investigator 26422
🇮🇹Valeggio sul Mincio Verona, Italy
Site Ref # / Investigator 49984
🇮🇹Rozzano, Italy
Site Ref # / Investigator 49589
🇮🇹Verona, Italy
Site Ref # / Investigator 49904
🇳🇱Alkmaar, Netherlands
Site Ref # / Investigator 49514
🇵🇹Coimbra, Portugal
Site Ref # / Investigator 49509
🇵🇹Lisboa, Portugal
Site Ref # / Investigator 49831
🇳🇱Amersfoort, Netherlands
Site Ref # / Investigator 49905
🇳🇱Den Haag, Netherlands
Site Ref # / Investigator 49910
🇳🇱Den Helder, Netherlands
Site Ref # / Investigator 49908
🇳🇱Schiedam, Netherlands
Site Ref # / Investigator 49653
🇪🇸Alicante, Spain
Site Ref # / Investigator 49649
🇪🇸Barcelona, Spain
Site Ref # / Investigator 49667
🇪🇸Cadiz, Spain
Site Ref # / Investigator 49510
🇵🇹Lisbon, Portugal
Site Ref # / Investigator 49513
🇵🇹Lisbon, Portugal
Site Ref # / Investigator 49680
🇪🇸Barcelona, Spain
Site Ref # / Investigator 49670
🇪🇸Barcelona, Spain
Site Ref # / Investigator 49685
🇪🇸Mostoles-Madrid, Spain
Site Ref # / Investigator 49476
🇬🇧Manchester, United Kingdom
Site Ref # / Investigator 49472
🇬🇧Wigan, United Kingdom
Site Ref # / Investigator 49980
🇮🇹Brescia, Italy
Site Ref # / Investigator 49986
🇮🇹Cagliari, Italy
Site Ref # / Investigator 50056
🇮🇹Ferrara, Italy
Site Ref # / Investigator 49597
🇮🇹Foggia, Italy
Site Ref # / Investigator 49824
🇮🇹Genoa, Italy
Site Ref # / Investigator 50051
🇮🇹Genoa, Italy
Site Ref # / Investigator 49981
🇮🇹Jesi (Ancona), Italy
Site Ref # / Investigator 49588
🇮🇹Messina, Italy
Site Ref # / Investigator 49596
🇮🇹Milano, Italy
Site Ref # / Investigator 49985
🇮🇹Modena, Italy
Site Ref # / Investigator 49949
🇮🇹Naples, Italy
Site Ref # / Investigator 49595
🇮🇹Novara, Italy
Site Ref # / Investigator 49947
🇮🇹Padova, Italy
Site Ref # / Investigator 49825
🇮🇹Udine, Italy
Site Ref # / Investigator 49594
🇮🇹Varese, Italy
Site Ref # / Investigator 50055
🇮🇹Verbania Pallanza, Italy
Site Ref # / Investigator 49376
🇫🇷Compiegne, France
Site Ref # / Investigator 49358
🇫🇷Cahors, France
Site Ref # / Investigator 49604
🇫🇷Aulnay Sous Bois, France
Site Ref # / Investigator 49613
🇫🇷Clermont-Ferrand, France
Site Ref # / Investigator 49607
🇫🇷Cannes, France
Site Ref # / Investigator 49356
🇫🇷Corbeil Essonnes, France
Site Ref # / Investigator 49340
🇫🇷Belfort, France
Site Ref # / Investigator 49622
🇫🇷Bourg en Bresse, France
Site Ref # / Investigator 49611
🇫🇷Boulogne Billancourt, France
Site Ref # / Investigator 49339
🇫🇷Besancon, France
Site Ref # / Investigator 49351
🇫🇷Bobigny, France
Site Ref # / Investigator 49365
🇫🇷Bordeaux, France
Site Ref # / Investigator 49334
🇫🇷Caen, France
Site Ref # / Investigator 49605
🇫🇷Dijon, France
Site Ref # / Investigator 49379
🇫🇷Grenoble, France
Site Ref # / Investigator 49361
🇫🇷Grenoble, France
Site Ref # / Investigator 49614
🇫🇷La Roche sur Yon, France
Site Ref # / Investigator 49373
🇫🇷Le Kremlin Bicetre, France
Site Ref # / Investigator 49325
🇫🇷Libourne, France
Site Ref # / Investigator 49620
🇫🇷Lievin, France
Site Ref # / Investigator 49375
🇫🇷Le Mans, France
Site Ref # / Investigator 49623
🇫🇷Limoges, France
Site Ref # / Investigator 49333
🇫🇷Lomme, France
Site Ref # / Investigator 49364
🇫🇷Lyon, France
Site Ref # / Investigator 49337
🇫🇷Lyon, France
Site Ref # / Investigator 49363
🇫🇷Lyon, France
Site Ref # / Investigator 49355
🇫🇷Lunel, France
Site Ref # / Investigator 49603
🇫🇷Mantes La Jolie, France
Site Ref # / Investigator 49626
🇫🇷Marseilles, France
Site Ref # / Investigator 49342
🇫🇷Marseilles, France
Site Ref # / Investigator 49345
🇫🇷Marseilles, France
Site Ref # / Investigator 49642
🇫🇷Narbonne, France
Site Ref # / Investigator 49330
🇫🇷Montivilliers, France
Site Ref # / Investigator 49323
🇫🇷Montpellier Cedex 5, France
Site Ref # / Investigator 5590
🇫🇷Mulhouse, France
Site Ref # / Investigator 49359
🇫🇷Paris, France
Site Ref # / Investigator 49331
🇫🇷Orleans, France
Site Ref # / Investigator 49618
🇫🇷Orange, France
Site Ref # / Investigator 49352
🇫🇷Paris Cedex 14, France
Site Ref # / Investigator 49602
🇫🇷Poissy, France
Site Ref # / Investigator 49343
🇫🇷Pau, France
Site Ref # / Investigator 49606
🇫🇷Pierre Benite, France
Site Ref # / Investigator 49349
🇫🇷Poitiers, France
Site Ref # / Investigator 49372
🇫🇷Rouen, France
Site Ref # / Investigator 49619
🇫🇷Roubaix, France
Site Ref # / Investigator 49328
🇫🇷Rennes, France
Site Ref # / Investigator 49609
🇫🇷Saint Aubin Les Elbeuf, France
Site Ref # / Investigator 49327
🇫🇷Saint Brieuc, France
Site Ref # / Investigator 49336
🇫🇷Saint Maurice, France
Site Ref # / Investigator 49598
🇫🇷Saint-Etienne, France
Site Ref # / Investigator 49366
🇫🇷Thionville, France
Site Ref # / Investigator 49616
🇫🇷Toulon, France
Site Ref # / Investigator 49322
🇫🇷Toulouse, France
Site Ref # / Investigator 49348
🇫🇷Toulouse, France
Site Ref # / Investigator 49324
🇫🇷Tours, France
Site Ref # / Investigator 49617
🇫🇷Valence, France
Site Ref # / Investigator 49371
🇫🇷Valenciennes, France
Site Ref # / Investigator 49629
🇫🇷Vannes, France
Site Ref # / Investigator 49480
🇩🇪Berlin, Germany
Site Ref # / Investigator 49577
🇩🇪Bremen, Germany
Site Ref # / Investigator 49441
🇩🇪Damp, Germany
Site Ref # / Investigator 49451
🇩🇪Chemnitz, Germany
Site Ref # / Investigator 5602
🇩🇪Cottbus, Germany
Site Ref # / Investigator 49446
🇩🇪Dresden, Germany
Site Ref # / Investigator 49455
🇩🇪Erfurt, Germany
Site Ref # / Investigator 49445
🇩🇪Sendenhorst, Germany
Site Ref # / Investigator 49560
🇩🇪Tuebingen, Germany
Site Ref # / Investigator 49647
🇪🇸Barcelona, Spain
Site Ref # / Investigator 49663
🇪🇸Cordoba, Spain
Site Ref # / Investigator 49693
🇪🇸Cadiz, Spain
Site Ref # / Investigator 49652
🇪🇸Elche, Spain
Site Ref # / Investigator 49651
🇪🇸Granada, Spain
Site Ref # / Investigator 49689
🇪🇸Lerida, Spain
Site Ref # / Investigator 49681
🇪🇸Granada, Spain
Site Ref # / Investigator 49695
🇪🇸Guadalajara, Spain
Site Ref # / Investigator 49686
🇪🇸Madrid, Spain
Site Ref # / Investigator 49665
🇪🇸Malaga, Spain
Site Ref # / Investigator 49691
🇪🇸Malaga, Spain
Site Ref # / Investigator 49679
🇪🇸Madrid, Spain
Site Ref # / Investigator 49650
🇪🇸Madrid, Spain
Site Ref # / Investigator 49654
🇪🇸Valencia, Spain
Site Ref # / Investigator 49697
🇪🇸Madrid, Spain
Site Ref # / Investigator 49683
🇪🇸Madrid, Spain
Site Ref # / Investigator 49692
🇪🇸Madrid, Spain
Site Ref # / Investigator 49664
🇪🇸Madrid, Spain
Site Ref # / Investigator 49696
🇪🇸Madrid, Spain
Site Ref # / Investigator 49688
🇪🇸Seville, Spain
Site Ref # / Investigator 5606
🇦🇺Camperdown, New South Wales, Australia
Site Ref # / Investigator 49504
🇦🇺New Lambton, New South Wales, Australia
Site Ref # / Investigator 49517
🇦🇹Graz, Austria
Site Ref # / Investigator 49502
🇦🇺Cairns, Australia
Site Ref # / Investigator 49508
🇦🇺Brisbane, Queensland, Australia
Site Ref # / Investigator 49505
🇦🇺Woodville, South Australia, Australia
Site Ref # / Investigator 49503
🇦🇺West Heidelberg, Victoria, Australia
Site Ref # / Investigator 49747
🇦🇹Bad Schallerbach, Austria
Site Ref # / Investigator 49329
🇫🇷Brest, France
Site Ref # / Investigator 49370
🇫🇷Creteil, France
Site Ref # / Investigator 49612
🇫🇷Carcassonne, France
Site Ref # / Investigator 49608
🇫🇷Gleize, France
Site Ref # / Investigator 49360
🇫🇷Lille, France
Site Ref # / Investigator 49601
🇫🇷La Rochelle, France
Site Ref # / Investigator 49374
🇫🇷Nantes Cedex 1, France
Site Ref # / Investigator 49600
🇫🇷Paris, France
Site Ref # / Investigator 49625
🇫🇷Paris, France
Site Ref # / Investigator 49344
🇫🇷Pessac, France
Site Ref # / Investigator 49382
🇫🇷Reims, France
Site Ref # / Investigator 49627
🇫🇷Provins, France
Site Ref # / Investigator 49346
🇫🇷Strasbourg, France
Site Ref # / Investigator 49466
🇩🇪Hattingen, Germany
Site Ref # / Investigator 49482
🇩🇪Gyhum, Germany
Site Ref # / Investigator 49552
🇩🇪Hamburg, Germany
Site Ref # / Investigator 49469
🇩🇪Freiburg, Germany
Site Ref # / Investigator 49442
🇩🇪Passau, Germany
Site Ref # / Investigator 49563
🇩🇪Munich, Germany
Site Ref # / Investigator 49583
🇬🇷Athens, Greece
Site Ref # / Investigator 49582
🇬🇷Thessaloniki, Greece
Site Ref # / Investigator 49592
🇮🇹Pisa, Italy
Site Ref # / Investigator 49948
🇮🇹Palermo, Italy
Site Ref # / Investigator 49992
🇮🇹Potenza, Italy
Site Ref # / Investigator 49978
🇮🇹Perugia, Italy
Site Ref # / Investigator 49974
🇮🇹Pescara, Italy
Site Ref # / Investigator 49989
🇮🇹Rome, Italy
Site Ref # / Investigator 49829
🇳🇱Leeuwarden, Netherlands
Site Ref # / Investigator 49994
🇮🇹Torino, Italy
Site Ref # / Investigator 50053
🇮🇹Vimercate, Italy
Site Ref # / Investigator 49906
🇳🇱Bergen op Zoom, Netherlands
Site Ref # / Investigator 49909
🇳🇱Almere, Netherlands
Site Ref # / Investigator 49907
🇳🇱Breda, Netherlands
Site Ref # / Investigator 49920
🇳🇱Den Haag, Netherlands
Site Ref # / Investigator 49902
🇳🇱Goes, Netherlands
Site Ref # / Investigator 26426
🇳🇱Rotterdam, Netherlands
Site Ref # / Investigator 49684
🇪🇸Barcelona, Spain
Site Ref # / Investigator 49645
🇪🇸Barcelona, Spain
Site Ref # / Investigator 5594
🇪🇸Castellon de la Plana, Spain
Site Ref # / Investigator 49669
🇪🇸Jaen, Spain
Site Ref # / Investigator 49687
🇪🇸Madrid, Spain
Site Ref # / Investigator 49666
🇪🇸Sant Joan Despi (Barcelona), Spain
Site Ref # / Investigator 49694
🇪🇸Toledo, Spain
Site Ref # / Investigator 49485
🇬🇧Brighton, United Kingdom
Site Ref # / Investigator 49470
🇬🇧Greater Manchester, United Kingdom
Site Ref # / Investigator 49648
🇪🇸Vic (Barcelona), Spain
Site Ref # / Investigator 49471
🇬🇧Harrogate, United Kingdom
Site Ref # / Investigator 49486
🇬🇧Oxford, United Kingdom
Site Ref # / Investigator 49778
🇧🇪Lokeren, Belgium
Site Ref # / Investigator 49802
🇧🇪Ottignies, Belgium
Site Ref # / Investigator 49764
🇧🇪Baudour, Belgium
Site Ref # / Investigator 49807
🇧🇪Brussels, Belgium