In-hospital outcome of transcatheter and surgical aortic valve replacement in patients with aortic valve stenosis: results from diagnosis procedure combination (DPC) data in Japa

Not Applicable

• Conditions: aortic valve stenosis

• Registration Number: JPRN-UMIN000024725
• Lead Sponsor: Department of Anesthesiology, Kansai Medical University Hospital

Brief Summary

This study aimed to compare in-hospital outcomes between TAVI and SAVR using a multi-center administrative database in Japan. TAVI produced better clinical outcomes in patients with aortic valve stenosis. The improved outcomes were particularly notable in patients aged 80 years or older. Measurements andMainResults: The mainstudyoutcomemeasurewasin-hospitalmortality.Basedonmultiplelogisticregressionanalysis using inverseprobabilityoftreatmentweighting,theoddsratioofin-hospitalmortalityforTAVI(relativetoSAVR)wascalculatedtobe0.36 (95% confidence intervals:0.13-0.98; p=0.04). Inpatientsaged80yearsorolder,theoddsratiowasevenlowerat0.34(95%confidence intervals: 0.15-0.73;p<0.01). Inaddition,theincidencesofreoperations,hemorrhagiccomplications,cardiactamponade,andpostoperative infections weresignificantly higherintheSAVRpatients.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2016-03-31
• Study Start: 2016-11-06
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 10000

Inclusion Criteria

Not provided

Exclusion Criteria

under 20 years of age at admission

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Hospital mortality

Secondary Outcome Measures

Name	Time	Method
28 day mortality