Association of gene polymorphisms with lung function decline in patients with asthma on inhaled corticosteroids

Not Applicable

• Conditions: Bronchial asthma

• Registration Number: JPRN-UMIN000002414
• Lead Sponsor: Kyoto University Graduate School of Medicine

Brief Summary

Kanemitsu Y, Matsumoto H, Izuhara K, Tohda Y, Kita H, Horiguchi T, et al. Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids. J Allergy Clin Immunol 2013;132:305-312 e303. -Nagasaki T, Matsumoto H, et al. Integrating longitudinal information on pulmonary function and inflammation using asthma phenotypes. J Allergy Clin Immunol. 133:1474-77 e2.2014 -Nagasaki T, Matsumoto H, et al. Using exhaled nitric oxide and serum periostin as a composite marker to identify severe steroid-insensitive asthma. Am J Respir Crit Care Med. 190:1449-52.2014 -Sunadome H, et al. IL4Ra and ADAM33 as genetic markers in asthma exacerbations and type-2 inflammatory endotype. Clin Exp Allergy, in press -Matsumoto H, et al. Staphylococcus aureus enterotoxin sensitization involvement and its association with CysLTR1 variant in different asthma phenotypes. Ann Allergy Asthma Immunol 2017, 118:197-203.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-09-01
• Study Completion: 2013-12-01
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

Not provided

Exclusion Criteria

Current smokers or ex smokers with 10 or more pack-years when the first spirometric data was taken. Patients with respiratory diseases other than asthma such as Churg Strauss syndrome, allergic bronchopulmonary aspergillosis, eosinophilic pneumonia, congestive heart disease, vocal cord dysfunction, interstitial pneumonia, bronchiectasia. Patients who are not adherent to ICS treatment (determined by physicians).

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Association between polymorphsims of candidate genes and annual decline of FEV1

Secondary Outcome Measures

Name	Time	Method
Association of levels of serum markers, and asthma control with annual decline of FEV1. Association of polymorphisms of candidate genes with levels of serum markers and asthma control