Effect of Beet-root Juice and PBM Treatments on Muscle Fatigue

Not Applicable

Recruiting

• Conditions: Healthy Aging; Health Care Utilization
• Interventions: Radiation: red-light therapy; Dietary Supplement: Beet-root juice; Radiation: sham light; Dietary Supplement: Placebo

• Registration Number: NCT05596474
• Lead Sponsor: Wake Forest University

Brief Summary

The goal of this randomized counterbalanced repeated measures study is to test beet-root juice supplementation and red light therapy augment forearm muscle endurance in apparently healthy older adults over 65 years of age. The main questions seek to answer the following question:

Does beet-root juice supplementation improve forearm muscle endurance compared to a placebo supplement?

Does red light therapy improve forearm muscle endurance compared to a sham light exposure?

Does beet-root juice supplementation in combination with red light therapy improve forearm muscle endurance compared to a placebo-sham light control?

Detailed Description

Not available

Study Timeline

• Study Start: 2022-09-09
• Study First Submitted: 2022-10-21
• Study First Submitted QC: 2022-10-26
• Study First Posted: 2022-10-27
• Status Verified: 2024-03
• Last Update Submitted: 2024-03-19
• Last Update Posted: 2024-03-20
• Primary Completion: 2024-08-31
• Study Completion: 2024-08-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Self-reports performing at least 30 minutes of light to moderate intensity physical activity 3 times per week for the last three months

Exclusion Criteria

• Currently smoke
• Have smoked within the last 6 months
• Are taking taking supplements known to increase blood nitrate levels
• Have a known kidney disease
• Have a known liver disease
• Have a known thyroid condition
• Have a known gastritis condition
• Are taking medications that are known to cause complications with nitrate supplementation
• Have known or reported joint pain within the dominant hand

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Beet-root juice plus sham light therapy	sham light	-
Placebo plus sham light therapy	sham light	-
Placebo plus red-light therapy	red-light therapy	-
Beet-root juice plus red-light therapy	Beet-root juice	-
Beet-root juice plus sham light therapy	Beet-root juice	-
Placebo plus red-light therapy	Placebo	-
Beet-root juice plus red-light therapy	red-light therapy	-
Placebo plus sham light therapy	Placebo	-

Primary Outcome Measures

Name	Time	Method
Total forearm work performed	During the forearm exercise fatigue protocol lasting up to 45 minutes	Work is the product of the number of times the forearm is activated multiplied by the amount of force produced by the forearm in kilograms.

Secondary Outcome Measures

Name	Time	Method
Forearm endurance	During the forearm exercise fatigue protocol lasting up to 45 minutes	The duration of time the participant takes to complete the forearm fatigue protocol
Intermuscular coordination	During the forearm exercise fatigue protocol lasting up to 45 minutes	Surface electromyography measurements of muscle activity

Trial Locations

Locations (1)

Wake Forest Univesity; 🇺🇸 Winston-Salem, North Carolina, United States