Autophagy Markers in Endometrial Polyps

Completed

• Conditions: Autophagy; Endometrial Polyp
• Interventions: Genetic: Beclin 1 gene

• Registration Number: NCT04706000
• Lead Sponsor: Muğla Sıtkı Koçman University

Brief Summary

The aim of this research is to evaluate autophagy markers in patients with endometrial polyps

Detailed Description

Endometrial polyp are benign formations that are frequently encountered in gynecology practice and have malignant potential. It may be asymptomatic in the clinic or may present with abnormal uterine bleeding. Although its pathophysiology has not been clearly revealed, there are many studies in the literature about it. However, the autophagy pathway emerges as a subject that has never been evaluated. In this study, the investigators would like to prospectively evaluate Beclin 1, LC3A / B and p62 markers in the autophagy pathway in endometrial polyp tissue samples by immunohistochemistry and reveal their importance.

Study Timeline

• Study Start: 2021-01-08
• Study First Submitted: 2021-01-08
• Study First Submitted QC: 2021-01-11
• Study First Posted: 2021-01-12
• Primary Completion: 2022-01-08
• Study Completion: 2022-02-01
• Status Verified: 2023-12
• Last Update Submitted: 2023-12-05
• Last Update Posted: 2023-12-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 30

Inclusion Criteria

• Patients over 35 years of age with a histopathologically confirmed diagnosis of endometrial polyp
• patients over the age of 35 whose histopathologically reported normal endometrial biopsy results.

Exclusion Criteria

• Are under the age of 35,
• those with cognitive dysfunction,
• diagnosed with any type of cancer
• who are under treatment for cancer,
• diabetes mellitus,
• hypertension,
• endometriosis,
• adenomyosis,
• chronic endometritis,
• have an acute or chronic illness,
• patients who have smoked and used alcohol in the last 10 years

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Study group	Beclin 1 gene	endometrial polyp
Control group	Beclin 1 gene	normal endometrium

Primary Outcome Measures

Name	Time	Method
autophagy marker	through study completion, an average of 1 year	p62 gene level

Trial Locations

Locations (1)

Mugla Sıtkı Kocman University Faculty of Medicine; 🇹🇷 Muğla, Turkey