Investigation of Autophagy Markers in Endometrial Polyps
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- autophagy marker
研究概览
简要总结
The aim of this research is to evaluate autophagy markers in patients with endometrial polyps
详细描述
Endometrial polyp are benign formations that are frequently encountered in gynecology practice and have malignant potential. It may be asymptomatic in the clinic or may present with abnormal uterine bleeding. Although its pathophysiology has not been clearly revealed, there are many studies in the literature about it. However, the autophagy pathway emerges as a subject that has never been evaluated. In this study, the investigators would like to prospectively evaluate Beclin 1, LC3A / B and p62 markers in the autophagy pathway in endometrial polyp tissue samples by immunohistochemistry and reveal their importance.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 35 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Patients over 35 years of age with a histopathologically confirmed diagnosis of endometrial polyp
- •patients over the age of 35 whose histopathologically reported normal endometrial biopsy results.
排除标准
- •Are under the age of 35,
- •those with cognitive dysfunction,
- •diagnosed with any type of cancer
- •who are under treatment for cancer,
- •diabetes mellitus,
- •hypertension,
- •endometriosis,
- •adenomyosis,
- •chronic endometritis,
- •have an acute or chronic illness,
- •patients who have smoked and used alcohol in the last 10 years
结局指标
主要结局
autophagy marker
时间窗: through study completion, an average of 1 year
p62 gene level
次要结局
未报告次要终点
研究者
Burak Sezgin
Principal investigator M.D. Burak Sezgin
Muğla Sıtkı Koçman University