ISRCTN16559899
Completed
N/A
A Multicentre Randomised and Comparative Trial to Assess the Tolerance, Efficacy and Pharmacokinetics of Escalating Doses of Casodex Versus Castration in the Treatment of Advanced Carcinoma of the Prostate
AstraZeneca Clinical Research Group (UK)0 sites248 target enrollmentAugust 19, 2002
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Prostate cancer
- Sponsor
- AstraZeneca Clinical Research Group (UK)
- Enrollment
- 248
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
2006 results in: https://www.ncbi.nlm.nih.gov/pubmed/16771791 (added 29/10/2019)
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Histologically/cytologically confirmed metastatic or locally advanced (T3 or T4\) prostate carcinoma. Confirmed within the last month
- •2\. Life expectancy of more than 3 months
- •3\. Prostate specific antigen (PSA) of at least five\-times upper limit of normal reference range
- •4\. Evaluable disease and fit to receive any of the treatment options
- •5\. No previous or concurrent systemic therapy for prostate cancer
- •6\. No radiotherapy to the prostate within the 3 months prior to entry into the trial
- •7\. No previous medical history of another malignancy within the past 5 years
- •8\. Adequate cardiac, renal and hepatic function
- •9\. Eastern Cooperative Oncology Group (ECOG) performance 3 or 4
Exclusion Criteria
- •Not provided at time of registration
Outcomes
Primary Outcomes
Not specified
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