Anaesthetic management guided by cellular oxygen metabolism measurements

Conditions: Adult patients undergoing elective open or laparoscopic abdominal surgery.

Registration Number: NL-OMON29588

Lead Sponsor: Amsterdam University Medical Centres, Location AMC

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 98

Inclusion Criteria

•Patients are at least 18 years old
•Patients undergo elective open or laparoscopic abdominal surgery with an expected minimal total incision size of 5 cm
•Patients are able and willing to give written informed consent

Exclusion Criteria

•Known photodermatoses of varying pathology and frequency
•Mitochondrial disease
•Porphyria
•Skin lesions on the upper arm which impede measurements
•Hypersensitivity to the active substance or the 5-ALA medicated plaster material
•Emergency surgery
•Reoperation for complications from recent surgery (within last three months)
•Participation in another study with interference with this study
•Pregnancy or breastfeeding

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mean mitoPO2 during abdominal surgery over time

Secondary Outcome Measures

Name	Time	Method
Secondary outcomes are the number, type and the respective effect of interventions that results in an increase of mitoPO2 after notification in which mitoPO2 aids decision making on anaesthetic management, the proportion of these incidences that were associated with a change in mitoPO2 and the proportion of patients this occurs in, the average cumulative duration of mitoPO2 below individual baseline value, the association of mitoPO2 with conventional hemodynamic monitoring measures and the SSI incidence after 30 days follow-up.