asal microbe modulation to manage chronic inflammatory conditions of the nose and paranasal sinuses
Not Applicable
- Conditions
- Health Condition 1: J328- Other chronic sinusitis
- Registration Number
- CTRI/2022/02/040464
- Lead Sponsor
- AIIMS Bhubaneswar
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Adults (more than 18 years);
Diagnosis of CRS based on American Academy of Otolaryngology-Head Neck Surgery guidelines, refractory CRS,
Atrophic Rhinitis based on clinical examination
Exclusion Criteria
Pregnancy, comorbidities that preclude travel for follow up, declining to be included in the study, a SNOT22 score of less than 10, LM score of less than 4 in cases of CRS.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Microbiome profile of patients with chronic inflammatory diseases of the nose and PNS <br/ ><br>2. Improved quality of life of patients with chronic inflammation of the nose and PNS (in CRS and Atrophic Rhinitis)Timepoint: 3 years
- Secondary Outcome Measures
Name Time Method 1. Normal nasal microbiome profile across age and gender <br/ ><br>2.The CT scan picture of the patients with the disease and following intervention <br/ ><br>3.The histopathological changes following intervention in Chronic inflammatory diseases <br/ ><br>4.To assess the change in the microbiome in these patients following intervention <br/ ><br>Timepoint: 3 years