Management of Childhood Pancytopenia

• Conditions: Pancytopenia
• Interventions: Diagnostic Test: Complete blood picture

• Registration Number: NCT03521947
• Lead Sponsor: Assiut University

Brief Summary

Pancytopenia is an important hematologic Problem.it is a decrease in all three cellular elements of peripheral blood leading to aneamia, leucopenia and thrombocytopenia.

Detailed Description

Pancytopenia usually presents with symptoms of bone marrow failure such as pallor, dysnea, brusing and increased tendency to infections.

The incidence of various disorders causing pancytopenia varies according to Geographical distribution and genetic mutations. It can result from :

* Failure of production of hematopoietic progenitors in bone marrow as in aplastic aneamia.

* Bone marrow infiltration by malignant cells as in acute leukemia.

* Antibodies mediated bone marrow suppression as in systemic lupus.

* Ineffective hematopoiesis and dysplasia as in nutrition deficiency.

* Peripheral sequestration of blood cells in over active reticuloendothelial system as in hypersplenism.

Pancytopenia is not a disease entity but a triad of findings that may result from primary or secondary bone marrow involvement.

Bone marrow aspiration and biopsy evaluation along with clinical correlation are important to evaluate the causes of pancytopenia and plan further investigations and treatment.

Pancytopenia can result from damage to bone marrow evidanced by low reticulocyte count, or increased destruction of the peripheral blood with increased reticulocyte count.

Bone marrow examination is a simple and safe invasive procedure for evaluating the causes of pancytopenia.

The hypoplastic marrow which occurs in 2% of pediatrics acute lymphoblastic leukemia may be misdiagnosed as aplastic aneamia.

Studies done have shown leukemia to be the second most common cause of pancytopenia in pediatrics, marginally behind aplastic aneamia.

Study Timeline

• Study First Submitted: 2018-04-17
• Status Verified: 2018-05
• Study First Submitted QC: 2018-05-09
• Last Update Submitted: 2018-05-09
• Study First Posted: 2018-05-11
• Last Update Posted: 2018-05-11
• Study Start: 2018-06-01
• Primary Completion: 2019-06-01
• Study Completion: 2019-12-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• All childrens and adolescents suffering from pancytopenia attending heamatology unit of pediatric department Assiut University Hospital will be included.

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Exclusion Criteria

• childrens and adolescents suffering from pancytopenia due to malignancy.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
One group of children below 18 years old	Complete blood picture	-

Primary Outcome Measures

Name	Time	Method
Availability	One year	Bone marrow examination for all cases \[evaluate the causes of pancytopenia and plan further investigations and treatment.\]

Secondary Outcome Measures

Name	Time	Method
Modification	One year	Guidelines for management of pancytopenia modified or not? \[Strategy of blood elements transfusion in treatment\]