Management of Childhood Pancytopenia in Heamatology Unit in Assiut University Hospital
试验速览
- 阶段
- 不适用
- 入组人数
- 25
- 主要终点
- Availability
研究概览
简要总结
Pancytopenia is an important hematologic Problem.it is a decrease in all three cellular elements of peripheral blood leading to aneamia, leucopenia and thrombocytopenia.
详细描述
Pancytopenia usually presents with symptoms of bone marrow failure such as pallor, dysnea, brusing and increased tendency to infections.
The incidence of various disorders causing pancytopenia varies according to Geographical distribution and genetic mutations. It can result from :
- Failure of production of hematopoietic progenitors in bone marrow as in aplastic aneamia.
- Bone marrow infiltration by malignant cells as in acute leukemia.
- Antibodies mediated bone marrow suppression as in systemic lupus.
- Ineffective hematopoiesis and dysplasia as in nutrition deficiency.
- Peripheral sequestration of blood cells in over active reticuloendothelial system as in hypersplenism.
Pancytopenia is not a disease entity but a triad of findings that may result from primary or secondary bone marrow involvement.
Bone marrow aspiration and biopsy evaluation along with clinical correlation are important to evaluate the causes of pancytopenia and plan further investigations and treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 4 Weeks 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All childrens and adolescents suffering from pancytopenia attending heamatology unit of pediatric department Assiut University Hospital will be included.
排除标准
- •childrens and adolescents suffering from pancytopenia due to malignancy.
结局指标
主要结局
Availability
时间窗: One year
Bone marrow examination for all cases \[evaluate the causes of pancytopenia and plan further investigations and treatment.\]
次要结局
- Modification(One year)
研究者
Asmaa Otify
Resident doctor of pediatrics
Assiut University