A double blind placebo controlled trial of citalopram for the treatment of coexisting alcohol dependence and major depressive syndrome for patients receiving naltrexone and clinical casemanagement: impact on drinking and mood symptomotology

Professor Doug Sellman0 sites220 target enrollmentSeptember 21, 2006

Overview

No summary available.

Registry

who.int

Start Date

September 21, 2006

End Date

TBD

Last Updated

6 years ago

Study Type

Interventional

Sex

All

Sponsor

Professor Doug Sellman

•Currently meets the DSM\-IV (APA 1994\) criteria for alcohol dependence (i.e. the presence of at least 3/7 DSM\-IV criteria for alcohol dependence in the month prior to presentation; \-currently meets the the DSM\-IV criteria for major depression (i.e. the presence of at least 5/9 DSM\-IV criteria for major depression in month prior to presentation and has no history of manic episodes);\-has a MADRS score of 20 plus at presentation.

•Any history of daily or nearly daily intravenous drug use for more than 2 weeks, or use of any opioid drugs in the previous 4 weeks; \-a history of psychosis of any sort;\-a clear history of mania or hypomania based on the DSM\-IV criteria;\-signifcant current risk of suicide or homicide;\-severe psychiatric symptoms requiring hospitalisation;\-evidence of any significant cerebral, renal, thyroid or cardiac disease;\-taken disulfiram, calcium carbimide, naltrexone, or antidepressant medication during the past 4 weeks;\-a history of alcoholic liver disease;\-if premenopausal female: pregnancy, nursing or refusing to use a reliable method of birth control;\-in prison or on home detention at any time during the past 4 weeks.