A diagnostic studie:Mannitol challenge test in patients with mild to moderate COPD
Recruiting
- Conditions
- Mild to moderate Chronic Obstructive Pulmonary Disease (COPD)
- Registration Number
- NL-OMON21900
- Lead Sponsor
- Dept. of Repiratory MedicineAcademic Medical CenterUniversity of AmsterdamP.O. Box 22700NL-1100 DE Amsterdam
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 23
Inclusion Criteria
1. Diagnosis of COPD conform the diagnostic criteria of the Global Initiative for Obstructive Lung Disease for stage I or II (mild to moderate) COPD www.goldcopd.org.
2. Age > 40 years
Exclusion Criteria
1. Subjects receiving treatment with inhaled corticosteroids of oral corticosteroids within the last 4 weeks.
2. Subjects who have had an exacerbation or a chest infection within the last 2 weeks prior to the study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Diagnostic tests:<br /><br>- Mannitol (Osmohale) challenge test (Index test).<br /><br>- Sputum induction to assess the degree of airway inflammation (Reference test)<br />
- Secondary Outcome Measures
Name Time Method - Influence of the mannitol challenge test on induced sputum (repeatability)<br /><br>- exhaled nitric oxide (NO) measured according to the ATS recommendations. <br /><br>- serum inflammatory proteins: albumin, alpha2 macroglobulin, Luminex assay. <br /><br>- Electronic nose: the Cyranose 320. A vital capacity volume is analyzed as smell print.<br /><br>- GC-MS: gas chromatography and mass spectrometry of breath samples (Philips Medical Research, Eindhoven, The Netherlands).<br />