NL-OMON52396招募中不适用
Myeloid cell reprogramming in aortic valve stenosis - Monocytes in aortic valve stenosis
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 400
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •- Age > 18 years
- •- Mild, moderate or Severe degenerative aortic valve stenosis as defined by
- •transthoracic echocardiography according to the 2017 ESC/EACTS guidelines for
- •the management of valvular heart disease.
- •- for the control group:
- •- 150 healthy subjects without aortic valve stenosis
- •- 50 subjects with aortic valve stenosis due to congenital biscuspid valve
排除标准
- •For patients and controls:
- •- Active auto-inflammatory or auto-immune diseases
- •- Anti-inflammatory drugs
- •- Vaccination less than one month before inclusion
- •- Bone marrow transplantation
- •- Active malignancy, except for local basal cell carcinoma or local squamous
- •cell skin carcinoma, that can be treated curatively by excision.
- •- History of endocarditis of the aortic valve
- •- History of radiation therapy aimed at the chest
- •- Acute ischemic cardiac event less than three months before inclusion
- •- Systemic inflammation less than one month before inclusion with fever and/or
- •for which antibiotics have been prescribed, with the exception for the use of
- •nitrofurantoin for a urinary tract infection without fever.
- •Extra exclusion for healthy control subjects:
- •- History of atherosclerotic cardiovascular events
- •- Current typical complaints of angina pectoris or intermittent claudication.
- •- Overt heart failure (NYHA class III/IV)
- •- Aortic valve stenosis on screenings echocardiography, that will be performed
- •before inclusion. Mild aortic valve sclerosis is allowed.
- •Extra exclusion for controls with aortic valve stenosis due to a bicuspid
- •- History of atherosclerotic cardiovascular events
- •- Current typical complaints of angina pectoris or intermittent claudication.
研究者
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