Cytokine Profiles in Children With Obstructive Sleep Apnea
- Conditions
- Obstructive Sleep Apnea Syndrome
- Registration Number
- NCT00456573
- Lead Sponsor
- University of Chicago
- Brief Summary
The purpose of this study is to compare the cytokine profile of tonsillar and peripheral blood mononuclear cells in patients with obstructive sleep apnea (OSA) and to compare the blood mononuclear cell cytokine secretion profile between patients with obstructive sleep apnea and controls without apnea.
- Detailed Description
We will recruit subjects with OSA about to undergo adenotonsillectomy and collect a blood sample and portion of their tonsils after the induction of general anesthesia. The mononuclear cells will be isolated from both these tissues and stimulated with different markers and cytokines assayed and compared. We will also recruit patients with no symptoms of OSA undergoing unrelated elective surgery and ascertain the absence of OSA by having the parents fill out a sleep questionnaire. We will then collect blood samples from these patients after the induction of anesthesia and examine the cytokine secretion profile and compare it to that of the children with OSA.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
- OSA documented by polysomnography and clinical symptoms.
- Patients with no symptoms of OSA and negative sleep questionnaire.
- Significant systemic disease except mild asthma
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method levels of cytokines released from PBMCs of OAS subjects and controls just prior to surgery
- Secondary Outcome Measures
Name Time Method cytokine level comparison between PBMCs and tonsillar lymphocytes within OAS groups at time of surgery
Trial Locations
- Locations (1)
University of Chicago
🇺🇸Chicago, Illinois, United States