KCT0005742尚未招募未知
Effectiveness and safety of celecoxib (Celebrex 200 mg) combined with Joins in the treatment of degenerative knee osteoarthritis: a randomized controlled trial
The Catholic University of Korea, Seoul St. Mary's Hospital0 个研究点目标入组 216 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 尚未招募
- 发起方
- 入组人数
- 216
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional Study
入排标准
- 年龄范围
- 50(Year) 至 o Limit（—）
- 性别
- All
入选标准
- •Adults over 50
- •Patients undergoing outpatient treatment in orthopedic surgery for osteoarthritis of the knee joint
- •Patients diagnosed with Kellgren-Lawrence grade II or III osteoarthritis of the knee by imaging examination
- •Patients with a pain VAS scale of 4 or more out of 10 with a pain in the knee joint during daily activities on flat ground
- •Patients confirmed by the examiner for no abnormal results in blood tests, etc.
- •Patients who are willing or able to follow doctor's instructions, including joint exercises
- •Patients not participating in other clinical trials
- •Patients who have received sufficient explanation for this clinical trial and agreed to participate
排除标准
- •Patients with secondary knee osteoarthritis
- •Patients with hypersensitivity reactions and serious side effects to Celebrex or Joins
- •Patients with inflammatory arthritis or crystalline arthritis
- •Local infection to the lower extremities of the pain area, sepsis, or previous neurological abnormalities.
- •Patients who underwent meniscus surgery on the knee joint in the painful area
- •Patients who underwent total knee arthroplasty within 180 days of the knee joint opposite the pain area
- •If there is construction or deformation of the knee joint in the pain area
- •Patients with serious heart-related diseases such as cardiac arrest, a history of cerebral infarction, or ischemic heart disease
- •Hemoglobin A1c level >8% of patients not managed by diabetes
- •Patients with high blood pressure with poor blood pressure control (Systolic Blood Pressure of> 150 mmHg or Diastolic Blood Pressure> 95 mmHg)
- •Patients taking PPI drugs for recurrent upper gastrointestinal ulcer or inflammatory bowel disease (such as Crohn's disease or ulcerative colitis)
- •Patients with abnormal liver function (ALT)> 2.0 times the upper limit of normal (ULN) or blood urea nitrogen (BUN) or serum creatinine> 2.0 times ULN)
- •Patients who took excessive narcotic analgesics for pain in the affected area before the clinical trial
- •Patients scheduled for surgery during the clinical trial period
- •Patients who received intraarticular injection treatment into the painful area of ??the knee within 3 months prior to the first visit
- •Patients who received systemic steroid treatment within 3 months prior to their first visit
- •Pregnant or lactating women
研究者
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