Clinical Characteristics and Microbiology of Healthcare Associated Pneumonia

Completed

• Conditions: Healthcare Associated Pneumonia

• Registration Number: NCT01966796
• Lead Sponsor: Far Eastern Memorial Hospital

Brief Summary

Background The prediction of multi-drug resistant (MDR) pathogens is a key issue in the management of health-care associated pneumonia (HCAP). Multiple risk factors have been proposed, some of which overlap with items of the pneumonia severity index (PSI). The aim of this study was to investigate the relationship between PSI and presence of MDR pathogens.

Methods Patients who were admitted to a tertiary-care hospital from January 2005 to December 2010 were screened by a discharge diagnosis of pneumonia. Patients were enrolled if they fulfilled the definition of HCAP by 2005 ATS/IDSA guideline.

Detailed Description

MDR bacteria were defined as Pseudomonas aeruginosa (P. aeruginosa), Enterobacter species, those not sensitive to second and third generation cephalosporins, Acinetobacter species, extended-spectrum β-lactamase (ESBL) Enterobacteriaceae such as Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae), Burkholderia cepacia (B. cepacia), Stenotrophomonas maltophilia (S. maltophilia), and methicillin resistant Staphylococcus aureus (MRSA).

The criteria for HCAP is defined as follows: patients who had been hospitalized in an acute care hospital for two or more days within the past 90 days; residents of a nursing home or long-term care facility; recipients of recent intravenous antibiotic therapy, chemotherapy or wound care within the past 30 days; or patients who attended a hospital or hemodialysis clinic.

Study Timeline

• Study Start: 2013-02
• Primary Completion: 2013-10
• Study Completion: 2013-10
• Study First Submitted: 2013-10-12
• Study First Submitted QC: 2013-10-17
• Study First Posted: 2013-10-22
• Results First Submitted: 2013-10-24
• Status Verified: 2020-09
• Results First Submitted QC: 2020-09-07
• Last Update Submitted: 2020-09-07
• Results First Posted: 2020-09-09
• Last Update Posted: 2020-09-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 530

Inclusion Criteria

• patients who had been hospitalized in an acute care hospital for two or more days within the past 90 days;
• residents of a nursing home or long-term care facility;
• recipients of recent intravenous antibiotic therapy, chemotherapy or wound care within the past 30 days;
• or patients who attended a hospital or hemodialysis clinic.

Exclusion Criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Number of Participants With MDR Pathogens	seven days after admission	MDR bacteria were defined as Pseudomonas aeruginosa (P. aeruginosa), Enterobacter species, those not sensitive to second and third generation cephalosporins, Acinetobacter species, extended-spectrum β-lactamase (ESBL) Enterobacteriaceae such as Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae), Burkholderia cepacia (B. cepacia), Stenotrophomonas maltophilia (S. maltophilia), and methicillin resistant Staphylococcus aureus (MRSA).
Pathogens of Healthcare Associated Pneumonia, Measured by the Number of Participants	7 days	sputum culture and sterile specimen such as blood or pleural effusion culture for healthcare associated pneumonia within seven days of admission

Trial Locations

Locations (1)

Far Eastern Memorial Hospital; 🇨🇳 New Taipei, Taiwan