Determination of optimal prophylactic dose of magnesium sulfate for prevention of atrial fibrillation after CABG surgery
- Conditions
- Atrial fibrillation.Atrial fibrillation and flutter
- Registration Number
- IRCT201211124365N15
- Lead Sponsor
- Vice chancellor for research of Mazandaran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 120
signing informed consent; candidate for elective CABG based on angiography; use of cardiopulmonary bypass (CBP) during surgery; no previous history of any cardiac dysrhythmias that is under treatment ( including AF); hemodynamic stability ( MAP>50, heart rate between 50-110); age between 35&75 years old.
Exclusion criteria: history of heart failure (Ejection Fraction less than 30%); more than 4 grafts; renal failure ( serum creatinine >1.5 in two consecutive test); hepatic failure ( liver function tests more than 1.5 times of normal value); history of COPD; hyperthyroidism; serum PH < 7.25 or > 7.55; postoperative MI; second or third degree AV block; need for pacemaker after surgery; reoperation for any reason; history of pervious cardiac surgery; anti-arrhythmic drugs consumption (except beta blocker).
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Atrial fibrillation. Timepoint: up to 3 days after operation. Method of measurement: ECG monitoring.
- Secondary Outcome Measures
Name Time Method PH. Timepoint: Before Before trial, during the operation,1st day, 2nd day and 3th day after operation, during the operation,1st day, 2nd day and 3th day after operation. Method of measurement: Laboratory kit.;K. Timepoint: Before Before trial, during the operation,1st day, 2nd day and 3th day after operation, during the operation,1st day, 2nd day and 3th day after operation. Method of measurement: Laboratory kit - mEq/L.;Mg. Timepoint: Before Before trial, during the operation,1st day, 2nd day and 3th day after operation, during the operation,1st day, 2nd day and 3th day after operation. Method of measurement: Laboratory kit - mg/dl.