Monitoring the effects of Antihypertensives(ACE Inhibitors / ARBS)in patients undergoing surgey

Not Applicable

Completed

• Conditions: Health Condition 1: I10-I16- Hypertensive diseases

• Registration Number: CTRI/2020/06/025892
• Lead Sponsor: Kasturba Medical College Manipal

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2021-10-12
• Last Update Posted: 17 October 2022

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

All adult hypertensive patients, of either gender on treatment with angiotensin converting enzyme inhibitors or Angiotensin receptor blockers who are scheduled for elective surgery will be enrolled in the study.

Exclusion Criteria

PREGNANT WOMEN

AGE <18YEARS

TERMINALLY ILL

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
incidence of deviation of mean blood pressure 30% from the baseline (as recorded during preoperative visit) intraoperatively <br/ ><br>Timepoint: Baseline (preop) <br/ ><br>Immediate preop <br/ ><br>After induction <br/ ><br>After intubation 1 min <br/ ><br>2 min <br/ ><br>3 min <br/ ><br>5 min <br/ ><br>10 min <br/ ><br>15 min <br/ ><br>30 min <br/ ><br>1 hr <br/ ><br>2 hr <br/ ><br>Hourly till extubation <br/ ><br>Before extubation <br/ ><br> <br/ ><br>

Secondary Outcome Measures

Name	Time	Method
1)Incidence of deviation of mean blood pressure 30% from the baseline (as recorded during preoperative visit) postoperatively <br/ ><br>2)Need for treatment of deviation in blood pressure (with vasoconstrictors/vasodilators) intraoperatively and postoperatively <br/ ><br>3)Any other adverse event attributable to ACE inhibitor/ARB continuation/discontinuation. <br/ ><br>Timepoint: After extubation <br/ ><br>1 min <br/ ><br>5 min <br/ ><br>30 min <br/ ><br>1 hr <br/ ><br>6 hr <br/ ><br>12 hr <br/ ><br>18 hr <br/ ><br>24 hr <br/ ><br>