To Evaluate Effects of Adding Letrozole To GnRh Antagonist In Pregnancy Outcome of Poor Ovarian Responders Candidate For InVitro Fertillization or IntraCytoplasmic Sperm Injection And Comparing It With Pregnancy Outcome of Poor Ovarian Responders Treated By GnRh Antsgonist Alone

Tehran University of Medical Sciences0 个研究点目标入组 70 人开始时间: 待定最近更新: 2018年2月22日

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•Inclusion Criteria: Infertile female who are reffered to InVitro Fertillization Department of Jaame_Zanan Hospital candidates for InVitro fertillization or IntraCytoplasmic Sperm Injection; females aged over 30 years old; females diagnosed as poor ovarian responders. Females should have at least one of listing criterias to be classified as poor responders: previous cancled cycle due to poor ovarian response in an InVitro fertillization or IntraCytoplasmic Sperm Injection cycle (defined as having 3 or less oovocytes retrieved or serum estradiol less than 500 pg/ml), serum Follicle_Stimulating Hormone over 10 U/ml and age above 40 years old. Exclusion criterias are: Infertile females having all inclusion criterias but do not wish to be included in the project; females who show letrozole hypersensivity reactions or serious intolerable side effects of letrozole; females over 50 years old; having endocrine disorders such as thyroid dysfunction, hyperprolactinemia or diabetes;previous ovarian surgery; having a follicle larger than 10 mm at third day of menstural cycle; history of OHSS in previous ART cycle; uncorrected Mullerian anomaly; active renal or hepatic diseases.

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