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临床试验/CTRI/2024/08/072223
CTRI/2024/08/072223尚未招募3 期

Efficacy of Lodhradi Facepack in Acne Vulgaris(Mukhadushika)

Dr Sumy Basheer1 个研究点 分布在 1 个国家目标入组 70 人开始时间: 2024年8月26日最近更新:

试验速览

阶段
3 期
状态
尚未招募
发起方
入组人数
70
试验地点
1
主要终点
Reduction in GAGS Score

研究概览

简要总结

Acne vulgaris is a chronic, inflammatory skin disease of the pilosebaceous unit, with open or closed comedones, papules, pustules, or nodules on the face or trunk, result in pain, erythema, hyperpigmentation, or scars. 9.4% of the global population has acne and 85% of them are teenagers. Treatments as per American Dermatological association guidelines include topical therapies, systemic antibiotics, hormonal agents, oral isotretinoin, physical modalities, complementary and alternative medicine, and dietary and environmental interventions. Though topical antibiotic therapies are the mainstay of grade II acne; adverse effects like irritant dermatitis, bacterial resistance are big concerns. Herbal medicines are becoming a promising strategy in cosmetics and skin care products and researches showed effectiveness of herbal and Ayurveda formulations in moderate acne vulgaris (Mukhadushika) with fewer adverse events. Mukhadushika charecterised by   Salmali-kantakaakara pidaka [lesions resembling the prickles of  silk cotton tree] , yoonam vakre [occurs in the  face  of young people]  sarujam (associated with pain),Ghana:[thick and dense lesion],medogarbha: [presence of fatty pultaceous material inside the lesion] The drugs having varnya(enhancing complexion), kushtaghna(curing skin diseases), kandoogna(antipruritic) and krimigna(Antihelminthic) actions are utilized in Ayurveda treatment. Lodhradi Facepack (LF) is a novel medicine formulated with bark of Lodhra (Symplocos cochinchinensis.Lour.), root of Manjishta (Rubia cordifolia L.), rhizhome of  Yashtimadhu (Glycyrrhiza glabra L.) and Multani-mitti (Fullers earth); which are having Mukhadushikahara, Varnya and Kandugna properties. Also unlike  antibiotics ,herbal medications have no side effects  like irritant dermatitis, bacterial resistance  etc  . Present medication  if proved to be effective can be used independently in moderate Acne vulgaris and adjuvant  in severe acne along with other medications.

研究设计

研究类型
Interventional
分配方式
Randomized
盲法
None

入排标准

年龄范围
18.00 Year(s) 至 35.00 Year(s)(—)
性别
All

入选标准

  • Participants with Global Acne Grading Score (GAGS) between 19-30 of age group 18-35yrs.

排除标准

  • Pregnant or Lactating women Patients under other medications for Acne vulgaris.

结局指标

主要结局

Reduction in GAGS Score

时间窗: 0th day | 56th day

次要结局

  • for standardisation of study drug physical parameters like ash value ,extractive value,TLC(Before starting study)

研究者

发起方
Dr Sumy Basheer
申办方类型
Other [self]
责任方
Principal Investigator
主要研究者

Sumy Basheer

Government Ayurveda college, Thiruvananthapuram

研究点 (1)

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