The Association Between Uremic Toxins and Outcomes and Comorbidities in Patients With CKD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Chronic Kidney Diseases
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
- Enrollment
- 500
- Locations
- 1
- Primary Endpoint
- all cause mortality
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
The aim of this cohort study is:
To investigate the etiology and epidemiology of comorbidities in CKD; To find out risk factors associated with the mortality of CKD; To find out uremic toxins which are related to the mortality and comorbidities of CKD; To focuse on the association between uremic toxins and inflammation, oxidative stress and nutritional status in CKD.
Detailed Description
To investigate the etiology and epidemiology of comorbidities in CKD; To find out risk factors associated with the mortality of CKD; To find out uremic toxins which are related to the mortality and comorbidities of CKD; To focuse on the association between uremic toxins and inflammation, oxidative stress and nutritional status in CKD.
Investigators
Ding Feng
Director of Devision of Nephrology
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Eligibility Criteria
Inclusion Criteria
- •age ≥18 years old;
- •clinically diagnosed with chronic kidney disease, according K/DOQI criteria.
Exclusion Criteria
- •acute kidney injury
- •history of kidney injury \<3 months
- •malignancy
- •pregnancy
- •incomplete clinical data
Outcomes
Primary Outcomes
all cause mortality
Time Frame: 5 years
Secondary Outcomes
- comorbidities(5 years)