NCT00849810终止不适用
Comparative Effects of Nebivolol Versus Metoprolol on 24-hour Blood Pressures and Basal Metabolic Rate: An Open-Label Study
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 1
- 试验地点
- 1
- 主要终点
- Primary Outcome is Pre- and Post-treatment Ambulatory Blood Pressure.
研究概览
简要总结
The purpose of the study is to compare the effects of nebivolol and metoprolol on 24-hour ambulatory blood pressure characteristics and basal metabolic rates in patients with hypertension.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18 years old or older
- •currently be treated at a University of MS Medical Center Internal Medicine Clinics
- •currently taking metoprolol succinate for hypertension
- •have their hypertension controlled (<140/90).
排除标准
- •uncontrolled hypertension
- •severe renal or moderate hepatic impairment
- •currently taking CYP 2D6 inducers/inhibitors
- •recent stroke (less than 6 months)
- •recent myocardial infarction (less than 6 months)
- •congestive heart failure
- •diagnosed obstructive sleep apnea
- •atrial fibrillation
- •arm circumference >50 cm
研究组 & 干预措施
Metoprolol to nebivolol
Experimental
metoprolol 25-200mg at a stable daily dose for 4 weeks, then change to nebivolol at a comparable stable dose (5-20 mg) for 4 -5 weeks.
干预措施: Metoprolol (Drug)
Metoprolol to nebivolol
Experimental
metoprolol 25-200mg at a stable daily dose for 4 weeks, then change to nebivolol at a comparable stable dose (5-20 mg) for 4 -5 weeks.
干预措施: Nebivolol (Drug)
结局指标
主要结局
Primary Outcome is Pre- and Post-treatment Ambulatory Blood Pressure.
时间窗: 4 weeks (pre- and post-treatment)
次要结局
未报告次要终点
研究者
Deborah Minor
Professor of Medicine
University of Mississippi Medical Center
研究点 (1)
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