Post-Poliosyndrome Treated With Intravenous Immunoglobulin (IvIg)
- Conditions
- Post-Polio Syndrome
- Registration Number
- NCT00231439
- Lead Sponsor
- Haukeland University Hospital
- Brief Summary
Inflammatory cytokines in the cerebrospinal fluid may contribute to the new muscle weakness, fatigue and pain experienced by patients with post-polio syndrome. Intravenousimmunoglobulin (IvIg) reduces this inflammation. The purpose of this study is to investigate the clinical effect of IvIg in post-polio syndrome.
- Detailed Description
Post-polio syndrome (PPS) is characterised by new muscle weakness, pain, and fatigue several years after the attack of acute polio. This leads to increased disability, and up to now only supportive therapy is available.
Patients with PPS lose more motor neurons than expected and surviving neurons fail to maintain neurogenic supply to enlarged motor units. New data report an increased level of inflammatory cytokines in the cerebrospinal fluid (CSF). Immune modulating therapy like IvIg could be an option and this pilot study is the first to investigate the clinical effect of IvIg in PPS. In addition, levels of cytokines in CSF and serum before and after treatment will be investigated.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
Post-polio syndrome diagnosed at Dept of Neurology, Haukeland University Hospital Walking ability -
Other autoimmune disorders Other ongoing autoimmune therapy Severe cardiopulmonary disease IgA deficiency Previous treatment of IvIg Wheelchair dependence
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Pain after three months Fatigue after 3 months Muscle strength after 3 months
- Secondary Outcome Measures
Name Time Method Pain, Fatigue, Muscle strength after 6 months. Changes in cytokine levels in CSF and serum