Detection of FIT- , fecal- and mucosa associated microbiome and microRNA in patients with suspected colorectal adenomas or cancer
- Conditions
- Microbiome, MicroRNA, Colorectal cancer, Adenomas
- Registration Number
- NL-OMON27020
- Lead Sponsor
- Erasmus Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 160
Inclusion Criteria
Participants are between 50-75 years old.
- Positive FIT in national CRC screening program
Exclusion Criteria
- Unwilling or not able to give informed consent
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The main study parameter will be the analysis of the microbiome and miRNA profile in relation to colorectal cancer and adenomas.<br>
- Secondary Outcome Measures
Name Time Method - To assess the possibility of using the microbiome in a FIT as screening tool for CRC<br /><br>- To assess the possibility of using miRNA panels in a FIT as screening tool for CRC<br /><br>- To assess the difference in diversity and composition of the microbiome in FIT, stool<br>sample and mucosal biopsy<br /><br>- To assess the difference in diversity and composition of miRNA in FIT, stool sample<br>and mucosal biopsy<br>