Novel Vascular Manifestations of Chronic Obstructive Pulmonary Disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- COPD
- Sponsor
- North Bristol NHS Trust
- Enrollment
- 55
- Locations
- 1
- Primary Endpoint
- Fractional Anisotropy
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
Cognitive impairment is a known consequence of cerebral small-vessel disease. Moderate to severe cognitive impairment has been shown in up to 60% of certain individuals with COPD and is likely to profoundly influence an individual's ability to manage their disease.
In addition to cerebral small vessel damage and cognitive dysfunction, other organs such as the heart, kidneys, and retina are likely to be susceptible to small-vessel damage in COPD. Several large population studies have shown that COPD is a significant independent risk factor for myocardial infarction, with the effect most marked in early, mild disease.
We propose to compare non-invasive MR brain imaging of white matter microstructure (diffusion tensor), cerebral perfusion (arterial spin labelling) and accumulated cerebral small vessel disease (cerebral microbleeds), in COPD patients to smokers without COPD. In addition we plan to explore mechanisms of cerebral small vessel disease in COPD by looking for associations between arterial stiffness, end organ vascular damage and cognitive function.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Subjects must give their signed and dated written informed consent
- •Subjects must be aged \>40 and ≤ 85
- •Subjects with a smoking history \> 10 pack years.
- •COPD group: Subjects with a FEV/FVC \<70%
Exclusion Criteria
- •Resting oxygen saturations \<92% on room air.
- •Long term oxygen therapy
- •Recent exacerbation of COPD (4 weeks)
- •Ischaemic heart disease
- •Cerebrovascular disease
- •Uncontrolled hypertension
- •Diabetes mellitus
- •Hepatic failure
- •Neurological disease
- •Non-cured tumours
Outcomes
Primary Outcomes
Fractional Anisotropy
Time Frame: upto 4 weeks
MRI Diffusion Imaging - measure of cerebral white matter microstructure
Secondary Outcomes
- Cardiac MRI(upto 4 weeks)
- Aortic Pulse Wave Velocity(upto 4 weeks)
- Arterial Oxygen Saturation(upto 4 weeks)
- Cerebral Microbleeds(upto 4 weeks)
- Micro-albuminuria(upto 4 weeks)
- FEV1 % predicted(upto 4 weeks)
- Retinal Photography(upto 4 weeks)
- Health Status(upto 4 weeks)
- MRI Cerebral Perfusion - ASL(upto 4 weeks)
- Cognitive Function(upto 4 weeks)