Impact of Adding Protein Supplementation to Exercise Training on Lean Body Mass and Muscle Strength in Burn Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- lean body mass
研究概览
简要总结
Burn injury causes continuous catabolism of the skeletal muscle resulting in decreased muscle strength, muscle mass and impairment of functional mobility. Purpose: The purpose of this study is to investigate the efficacy of combination of exercise training and protein supplementation on lean body mass (LBM) and muscle strength in patients with severe burn.
详细描述
Sixty participants with severe burn > 30% total body surface area (TBSA) were randomly distributed into 4 equal groups of 15 participants per group. Group A (Protein+ Exercise group) received oral protein supplementation, exercise program and traditional burn care, group B (Protein group) received oral protein supplementation and traditional burn care, group C (Exercise group) received exercise program and traditional burn care, group D (Control group) received traditional burn care. LBM was measured using Dual-energy x-ray absorptiometry (DXA) while muscle strength was measured using Biodex 3 Dynamometer System before treatment and 12 weeks after treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healed deep partial-thickness thermal burn
- •> 30% of TBSA and
- •the exercise program started after healing of the burn (after burn injury by 6 weeks)
排除标准
- •conditions that may affect on participation in the exercise program as a recent coronary disease, uncontrolled hypertension, orthopedic problems limiting exercise, abnormal cardiac stress test, pregnant women, refusal to participate in a physical activity program,
- •presence of psychological or cognitive disorders (aggressive behavior, impulsivity, dementia)
- •food intolerance to milk protein products.
研究组 & 干预措施
Protein+ Exercise group
Received oral protein supplementation, exercise program and traditional burn care
干预措施: whey protein supplementation powder (Inkospor X-TREME; France) (Dietary Supplement)
Protein+ Exercise group
Received oral protein supplementation, exercise program and traditional burn care
干预措施: Exercise training program (Other)
Protein+ Exercise group
Received oral protein supplementation, exercise program and traditional burn care
干预措施: traditional burn care (Other)
Protein group
Received oral protein supplementation and traditional burn care
干预措施: whey protein supplementation powder (Inkospor X-TREME; France) (Dietary Supplement)
Protein group
Received oral protein supplementation and traditional burn care
干预措施: traditional burn care (Other)
Exercise group
Received exercise program and traditional burn care
干预措施: Exercise training program (Other)
Exercise group
Received exercise program and traditional burn care
干预措施: traditional burn care (Other)
Control group
Received traditional burn care
干预措施: traditional burn care (Other)
结局指标
主要结局
lean body mass
时间窗: after 12 week of intervention
The QDR 4500A densitometry system DXA (Hologic Inc., Bedford, USA) was used according to the manufacturer instructions for calculating LBM
次要结局
- muscle strength(after 12 week of intervention)
研究者
Nesma Morgan Allam
Lecturer
Cairo University