Inspiratory Muscle Activation Pattern Analysis in Assisting Precision in Inspiratory Muscle Training in Patients With Chronic Respiratory Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1
- 试验地点
- 2
- 主要终点
- Diaphragm and Sternocleidomastoid muscle activation
研究概览
简要总结
Background & Objective: Inspiratory muscle training (IMT) is known to improve strength and endurance of inspiratory muscles. However, clinical beneficial effects of IMT for patients with chronic respiratory disease remain inconclusive.
The purposes of the study are to investigate in patients with chronic respiratory disease: (Year 1) main (diaphragm) and accessory inspiratory muscle (sternocleidomastoid muscle) activation pattern during various IMT loading using group-based trajectory modeling (GBTM); and (Year 2) effectiveness of individualized IMT program (based on results of Year 1) on clinical outcomes. Methods: (Year 1) Patients with chronic respiratory disease with inspiratory muscle weakness will be recruited for the study. Patients will perform 3 inspiratory loading tests (15%, 30%, and 50% of maximum inspiratory pressures) on 3 separate days with the sequence will be randomized. Surface electromyography (EMG) of diaphragm and sternocleidomastoid muscle will be used to use inspiratory muscle activation during various conditions. Other outcomes include maximum inspiratory pressure, and functional exercise capacity will be measured. Inspiratory muscle activation will be used for GBTM analysis. Patient will then be trained with individualized IMT program based on the GBTM analysis input form results of Year 1.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age > 20 years old
- •has been diagnosis of chronic obstructive pulmonary disease with stable clinical condition with no infection or acute exacerbation in the previous four weeks
- •can cooperate with the measurements of this study
排除标准
- •any clinical diagnosis that will influence the measurement, including any history of
- •neuromyopathy
- •angina, acute myocardial infarction in the previous one month
- •pregnancy
- •participated in inspiratory muscle training program in the previous three months
- •any psychiatric or cognitive disorders, for example: Mini-Mental State Examination (MMSE) < 24, that will disturb the communication and cooperation of the study
结局指标
主要结局
Diaphragm and Sternocleidomastoid muscle activation
时间窗: through the completion of the inspiratory loading tests condition; it would take about 3 minutes
Root mean square values during different conditions
Pulmonary function
时间窗: About five minutes to complete
Forced expiratory volume in one second, forced vital capacity, residual volume, total lung capacity
The mean median frequency of diaphragm and sternocleidomastoid muscle
时间窗: In five minute after the completion of the loaded inspiratory muscle test condition
The power spectrum is divided into two equal areas of the frequency value by median frequency to exam muscle fatigability
Maximal inspiratory pressure test
时间窗: About three minutes to complete
Maximal inspiratory pressure
Functional exercise capacity using the six-minute walk test
时间窗: The six-minute walk test needs six minute to complete the test
The six-minute walk test is commonly performed to evaluate functional exercise capacity. The six-minute walk test was performed according to the guidelines, and the distance walked in the test presented as functional exercise capacity
Heart rate
时间窗: The six-minute walk test needs six minute to complete the test
Heart rate is measured at rest, during six-minute walk test
Blood pressure
时间窗: Before and immediately after the six-minute walk test;it takes less than one minute to measure blood pressure
systolic and diastolic pressure are measured at rest, after six-minute walk test
Perceived dyspnea
时间窗: It takes less than one minute to evaluate perceived dyspnea
Rating of perceived dyspnea is measured by using Borg scale at rest, during six-minute walk test, inspiratory loading tests. The most widely used tool is the "Borg scale", with rating ranges from 0 (nothing at all) to 10 (extremely dyspnea).
Oxygen saturation
时间窗: The six-minute walk test needs six minute to complete the test; through the completion of the inspiratory loading tests condition; it would take about 3 minutes
Oxygen saturation is continuously monitored by pulse oximetry throughout six-minute walk test, inspiratory loading tests
次要结局
未报告次要终点