Response of Fatty Liver to Lifestyle Modification in Psoriasis Patients
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Psoriasis Area and Severity Index
研究概览
简要总结
Several recent reports have shown an increased prevalence of nonalcoholic fatty liver disease (NAFLD) in those with psoriasis, which may reflect the increased occurrence of metabolic syndrome in this patient population.
详细描述
the recruitment of 60 fatty live men with chronic disease, psoriasis, will be classified to lifestyle modification group (foe 12 weeks, this patients will take supervised energy or diet restriction program plus their usual immunosuppressive drugs ) and control group will continue their drug program only)
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •psoriasis obese patients with coexisting fatty liver
- •chronic plaque psoriasis
- •patients who will not show any change in immuno-modulating psoriasis therapies for at least five months before participation in the study.
排除标准
- •no metabolic syndrome
- •no renal or cardiac or pulmonary disorders
- •other types of psoriasis
结局指标
主要结局
Psoriasis Area and Severity Index
时间窗: It will be measured after 12 weeks
it is an index used to measure level and severity of psoriasis
次要结局
- Dermatology Life Quality Index(It will be measured after 12 weeks)
- triglycerides(It will be measured after 12 weeks)
- BMI(It will be measured after 12 weeks)
- ALT(It will be measured after 12 weeks)
- AST(It will be measured after 12 weeks)
- waist circumference(It will be measured after 12 weeks)
研究者
Ali Mohamed Ali ismail
lecturer of Physical Therapy for Cardiovascular / Respiratory Disorder and Geriatrics, Faculty of Physical Therapy, Cairo University
Cairo University