The Effect of Chronic Consumption of a Cranberry Beverage on Inflammation and Oxidative Stress in Healthy But Overweight/Obese Subjects: A Randomized Clinical Trial

Tufts University2 sites in 1 country79 target enrollmentFebruary 2012

ConditionsInflammation

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Inflammation
Sponsor: Tufts University
Enrollment: 79
Locations: 2
Primary Endpoint: Change in biomarkers of oxidative stress compared with placebo.
Status: Completed
Last Updated: 9 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The objective of this randomized, double-blind, placebo-controlled, parallel-design clinical trial is to investigate the potential antioxidant benefits of a cranberry beverage. The investigators hypothesize the chronic consumption of this beverage will improve indices of oxidative stress, inflammation, endothelial function, and glucoregulation. The investigators also hypothesize that these benefits will be particularly evident following an oral glucose tolerance test.

Registry

clinicaltrials.gov

Start Date

February 2012

End Date

February 2013

Last Updated

9 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Tufts University

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Men \& women, aged 30-70 years
•BMI 27-34.9 kg/m2
•waist:hip ratio \> 0.8 for women and \> 0.9 for men

Exclusion Criteria

•Cigarette smoking and/or nicotine replacement use within last 6 months
•Individuals taking estrogen or testosterone
•Use of cholesterol-lowering medications
•Use of blood pressure-lowering medications
•Regular use (\> 1x/wk) of any stomach acid-lowering medications or laxatives (including fiber supplements)
•Cardiovascular (heart) disease
•Gastrointestinal disease
•Kidney disease
•Endocrine disease: including diabetes, untreated thyroid disease
•Rheumatoid arthritis