Mindfulness-oriented Recovery Enhancement (MORE) for Cancer Pain Relief

Phase 2

Recruiting

• Conditions: Cancer Pain; Chronic Pain
• Interventions: Other: Standard of Care for Pain Management; Behavioral: MORE treatments

• Registration Number: NCT05877521
• Lead Sponsor: Memorial Sloan Kettering Cancer Center

Brief Summary

The purpose of this study is to evaluate whether or not mindfulness-based interventions/MBIs may help reduce chronic pain in participants who have cancer-related chronic pain. MBIs are therapeutic programs that use mindfulness meditation practices to help people focus on the present moment, as well as encourage acceptance of thoughts, emotions, and body sensations. The researchers think that an MBI treatment called Mindfulness-oriented Recovery Enhancement (MORE) may help people who are experiencing cancer-related chronic pain.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-05-16
• Study First Submitted: 2023-05-17
• Study First Submitted QC: 2023-05-17
• Study First Posted: 2023-05-26
• Status Verified: 2025-05
• Last Update Submitted: 2025-05-16
• Last Update Posted: 2025-05-21
• Primary Completion: 2027-05-16
• Study Completion: 2027-05-16

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 76

Inclusion Criteria

• English speaking
• Age ≥ 18 years or older
• A history of cancer with no restrictions placed on type of cancer
• Determined to be either no-evidence of disease or stable oncological disease by referring or study physicians/advanced practice providers
• Having a pain (musculoskeletal, generalized, or neuropathic) rating of 4 or greater in worst pain on a 0-10 numerical rating scale in the preceding week
• Having had pain for at least 3 months and at least 15 days with pain in the preceding 30 days
• Willing to adhere to all study-related procedures, including randomization to one of two treatment arms: MORE or WLC
• Ability to attend video-call session and a quiet/private location

Exclusion Criteria

• Active suicidality or schizophrenia
• Plan to initiate palliative radiation or interventional pain procedure within the next 12 weeks
• Cognitive impairment preventing completing PRO independently or participate in virtual MORE as evaluated by study clinicians

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Wait List Control (WLC) Usual Care Procedure	Standard of Care for Pain Management	Participants in the WLC group continue to receive their standard medical care and pain management as prescribed by their physicians or other health care providers.
8-hour MORE treatments	MORE treatments	Patients in the 8-hour MORE format will receive one 2hrs treatment a week for 4 consecutive weeks (as per study schema: from week 1 to week 4).
16-hour MORE treatments	MORE treatments	Patients in the 16-hour MORE format will receive one 2hrs treatment a week for 8 consecutive weeks (as per study schema: from week 1 to week 8).
2-hour MORE treatments	MORE treatments	Patients in the 2-hour MORE format will receive one 2hrs treatment (as per study schema: in week 1).

Primary Outcome Measures

Name	Time	Method
Rate of participant enrollment to the study	12 months	Feasibility of the intervention will be determined by Rate of participant enrollment to the study

Trial Locations

Locations (1)

Memorial Sloan Kettering Cancer Center (All Protocol Activities); 🇺🇸 New York, New York, United States