Comparative evaluation of nebulised Dexmedetomidine and Lignocaine on haemodynamic stress response to laryngoscope and intubation - A prospective, randomized clinical study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- 1) Dexmedetomidine (1microgram/kg) serves as a very useful anaesthesia adjuvant to control haemodynamic stress response to laryngoscope and intubation without any significant adverse effects.
研究概览
简要总结
The Study ’ Comparative evaluation of nebulized Dexmedetomidine and Lignocaine on haemodynamic stress response to laryngoscopy and intubation-A prospective, randomized clinical study.’ Will be done in Gajra Raja Medical College, Gwalior MP on sample size of 60 Patients for the time period of 8 months after fulfilling the eligibility criteria will be chosen by simple randomization.Patients will be subsequently randomized into 3 groups by closed enveloped technique. Group D- Patient Will be receiving nebulized Dexmedetomidine 1mjcrogram/kg.
Group L- will be receiving nebulized Lignocaine 4mg/kg. Group C- will be receiving normal saline 5ml. The Patient Will be kept under observation after intubation for noting the vital parameters
like heart rate, blood pressure ( Systolic SBP and Diastolic DBP) , mean arterial pressure, pulse oximetry (spo2) at the following time points: baseline,after nebulization,post larygoscopy/intubation at 1,5,10,20,30,40,50,60 and 90mins. After the study end, results will be obtained. Primary aim of this study is to evaluate the role of nebulized dexmedetomidine as a premedication in attenuation the stress response to larygoscopy and intubation and to compare it with nebulized Lignocaine.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant, Investigator, Outcome Assessor and Date-entry Operator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patient giving consent to participate in study 2) Age between 18-60yrs 3) American Society of Anaesthesiologist Grade 1 & 2.
排除标准
- 未提供
结局指标
主要结局
1) Dexmedetomidine (1microgram/kg) serves as a very useful anaesthesia adjuvant to control haemodynamic stress response to laryngoscope and intubation without any significant adverse effects.
时间窗: These outcomes are based on observations made after giving nebulized drugs 10 minutes before intubation to 90th minutes intraoperatively.
2) Efficacy of nebulized dexmedetomidine in attenuation of the haemodynamic stress response compared to nebulized Lignocaine will be significantly higer in ASA-1 and 2 Patients with respect to HR, SBP, DBP and MAP.
时间窗: These outcomes are based on observations made after giving nebulized drugs 10 minutes before intubation to 90th minutes intraoperatively.
次要结局
- Nebulized Lignocaine also attenuated the haemodynamic stress response during intubation and laryngoscopy compared to normal saline.(These outcomes are based on observations made after giving nebulized drugs 10 minutes before intubation to 90th minutes intraoperatively.)
研究者
Dr Tridha Ghosh
Gajra Raja Medical College, Gwalior, MadhyaPradesh