Investigating the Effect of Onopordon Acanthium Seed on Primary Hypertension Reduction in Patients under Treatment by Losarta
- Conditions
- Primary hypertension.Essential (primary) hypertension
- Registration Number
- IRCT2013020712391N1
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 25
Inclusion Criteria: Aged between 30 and 60; SBP>= 140; DBP >= 90 mmHg; Patient under treatment by Losartan (50 mg);
Existence of malignant hypertension, i.e. blood pressure higher than 200/140 mmHg which needs multi-drug treatment or emergency IV drug infusion to control blood pressure; History of secondary hypertension ; Existence of end organ damages (EOD); Sudden increase of blood pressure to greater than 15 mmHg at any time during the study; Existence of any kind of cardiac arrhythmias; Symptomatic valvular heart diseases (except mitral valve prolapse); Liver function disorders; Pregnancy and lactation; Cured or uncured malignancy during the last 5 years; Serum potassium >5.2 or <3.5 mEq/L in the first visit; Drug or alcohol usage background; Any kind of disorder (medical or surgical) which can interfere the study
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Systolic Blood Pressure. Timepoint: Beginning of the project, End of the second week, end of the fourth week, end of the sixth week, end of the eighth week. Method of measurement: Measuring by mercury sphygmomanometer in millimetres of mercury (mmHg).;Diastolic Blood Pressure. Timepoint: Beginning of the project, End of the second week, end of the fourth week, end of the sixth week, end of the eighth week. Method of measurement: Measuring by mercury sphygmomanometer in millimetres of mercury (mmHg).
- Secondary Outcome Measures
Name Time Method