Influence of Anesthetics on Sedation and Antinociception: an Analysis of Auditory Evoked, Visceral Evoked and Heat Evoked Potentials
Overview
- Phase
- Phase 4
- Intervention
- Remifentanil
- Conditions
- Healthy
- Sponsor
- Technical University of Munich
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- influence of different drugs on evoked responses
- Status
- Completed
- Last Updated
- 18 years ago
Overview
Brief Summary
The aim of the present study is to investigate and quantify the influence of commonly used anesthetics on auditory and pain evoked potentials.
Detailed Description
During surgery patients are exposed to different auditory and sensory stimuli. In this study we investigate the influence of different anesthetics to alertness and nociception. In addition to auditory stimuli (AEP as a measure of sedation), Contact Heat Evoked Potential Stimuli (CHEPS), and esophageal evoked potentials from the lower 1/3 of the esophagus are measured to quantify the effects of anesthetics. 60 Volunteers are enrolled into this study. For each drug, three different levels are measured: * level 1 no medication * level 2 low dose of medication * level 3 light sedation dose (volunteer responds to command) Four drugs are measured in the study: propofol, sevoflurane, S-ketamine and remifentanil.
Investigators
Eligibility Criteria
Inclusion Criteria
- •American Society of Anesthesiologists (ASA) physical status 1-2
Exclusion Criteria
- •drugs that effect the central nervous system
- •neurological or psychiatric diseases
- •contraindications against propofol, sevoflurane, S-ketamine or remifentanil
- •any damages or loss of hearing
- •heartburn or any stomach diseases
Arms & Interventions
1
remifentanil
Intervention: Remifentanil
2
propofol
Intervention: Propofol
3
sevoflurane
Intervention: Sevoflurane
4
s-ketamine
Intervention: S-Ketamine
Outcomes
Primary Outcomes
influence of different drugs on evoked responses
Time Frame: 2 hours
Secondary Outcomes
- discrimination of antinociceptive, visceral-perceptive and sedative effects of anesthetics(2 hours)
- quantification of anesthetic components of propofol, sevoflurane, S-ketamine and remifentanil(2 hours)