跳至主要内容
临床试验/NCT06451042
NCT06451042已完成不适用

FET-PET/MRI Based Treatment Planning for Glioblastoma Multiforme in Post-Surgical Patients (FET-TREAT)

Sunnybrook Health Sciences Centre1 个研究点 分布在 1 个国家目标入组 11 人开始时间: 2024年7月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
11
试验地点
1
主要终点
Difference in radiation treatment volume as determined by FET-PET/MRI compared to standard of care MRI.

研究概览

简要总结

Glioblastoma multiforme (GBM) represent the most common primary brain malignancy and prognosis remains poor. The most common subtype is glioblastoma which has a 5-year survival rate of approximately 5%. Despite advances in MRI techniques, accurately determining total extent of tumor remains a challenge. The result is incomplete treatment resulting in reduced survival or overtreatment resulting in avoidable treatment related morbidity. A more accurate means of assessing tumor extent is needed to guide management to improve patient survival and quality of life.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Each participant must meet all of the following inclusion criteria to participate in this study:
  • ≥ 18 years of age
  • Diagnosis of glioblastoma multiforme
  • Post-maximally safe surgical resection
  • No prior radiation or systemic treatment for high grade glioma
  • Able to tolerate PET/MRI scan with intravenous contrast
  • Willing to provide informed consent

排除标准

  • All participants meeting any of the following exclusion criteria at baseline screening will be excluded from participation in this study:
  • MRI contraindication
  • Creatinine clearance < 30mL/min
  • Inability to lie still for 60 minutes
  • Gadolinium allergy
  • Positive pregnancy test
  • Breastfeeding
  • Patient unable to follow the protocol for any reason

结局指标

主要结局

Difference in radiation treatment volume as determined by FET-PET/MRI compared to standard of care MRI.

时间窗: 12 months

Volume difference measured in cubic centimetres

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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