A comparison of the rate of rise of transcutaneous carbon dioxide during apnoeic oxygenation in microlaryngoscopy using transnasal humidified rapid insufflation ventilatory exchange (THRIVE) versus low flow tracheal insufflation: a randomised control trial

Not Applicable

• Conditions: laryngeal pathology; carbon dioxide rate of rise; Anaesthesiology - Anaesthetics; Respiratory - Other respiratory disorders / diseases

• Registration Number: ACTRN12620001268932
• Lead Sponsor: Monash Health Anaesthetic Department

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-11-25
• Last Update Posted: 30 November 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

All patients over the age of 18 years undergoing microlaryngoscopy procedure

Exclusion Criteria

BMI > 40
Pregnancy
Expected > 30 minutes procedure time
Resting saturations on air < 92%

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Rate of rise of TcCO2 per unit time [Time zero will be the moment that the surgical laryngoscope first enters the patient’s oral cavity. TcCO2 is recorded continuously and electronically by the Sentec TcCO2 device. The TcCO2 will be measured every minute. The rate of CO2 rise will be calculated over the operative time period.]

Secondary Outcome Measures

Name	Time	Method
Maintenance of oxygenation[Oxygen saturation (SpO2) at time zero; and at the completion of surgery will be recorded. The times at which SpO2 falls to 95% and 92% will also be recorded, should these events occur. ];Surgical conditions - this will seek the opinion of the surgical conditions from our otolaryngologist performing the microlaryngoscopy. This will be recorded immediately after surgery on a proforma describing quality surgical field as poor, adequate or excellent, with a free text comments section. [To be documented by consultant surgeon immediately after procedure];Oral, nose or throat discomfort as reported by patient[Discomfort defined by patient complaining of mucosal dryness or pain immediately post operatively and at day 3 -5 post operatively by telephone will be recorded on a scale of none, mild, moderate or severe. ]