a study between two medicated locking solutions in Catheter related infections in patients undergoing dialysis via permacath
Not Applicable
- Conditions
- Health Condition 1: N186- End stage renal disease
- Registration Number
- CTRI/2022/11/047358
- Lead Sponsor
- MPUH
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients with Hemodialysis TCC that have been in place for at least 14 days with probable/ possible CRBSI as defined by KDOQI.
Exclusion Criteria
CRBSI within 14 days of insertion of TCC
Patients with severe sepsis, septic shock, hypotension or who are considered otherwise unstable
Patient with prosthetic valve
Patient with signs of metastatic deep-seated infection such as osteomyelitis or septic pulmonary infarcts or endocarditis (as evidenced by vegetation on an echocardiogram), or septic thrombosis
Patients with tunnel or catheter exit site infection or infusion port pocket abscess as manifested by purulence at the exit site or inflammation with erythema or induration of >1 cm in diameter.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method outcomes - <br/ ><br>1. removal of permacath (TCC) due to persistent CRBSI <br/ ><br>2. removal of permacath (TCC) due to any other cause <br/ ><br>3. effectiveness of locking solution by disappearance of fever and blood culture becoming sterileTimepoint: above mentioned outcomes <br/ ><br>at day 7 - outcome 1,2,3 <br/ ><br>at day 30 - outcome 1,2 <br/ ><br>at day 50 - outcome 1,2
- Secondary Outcome Measures
Name Time Method To compare the efficacy of Ethanol lock V/S antibiotic lock in clearance of the infection as documented by negative blood cultures one week after completion of antibiotic therapy.Timepoint: 1 week