Follow-up and Survival of Cirrhotic and Non Cirrhotic Patients With Portal Vein Thrombosis Treated With Transjugular Intrahepatic Portosystemic Shunt
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Outcome of TIPS for PVT in patients with and without cirrhosis
研究概览
简要总结
Portal vein thrombosis (PVT) is defined as an obstruction of the portal vein. The prevalence of PVT is 10-25% and incidence is about 16% in cirrhotic patients. PVT leads to increased intrahepatic resistance, decreased portal velocities, splanchnic vasodilatation, and stagnant flow.
Portal vein recanalization (PVR) with transjugular intrahepatic portosystemic shunt (TIPS) is aimed at restoring main portal vein (PV) flow in chronic PVT. In this study, we will review the safety and outcomes of this approach.
详细描述
Portal vein thrombosis (PVT) is a fairly common complication of liver cirrhosis. Importantly, occlusive PVT might influence the prognosis of patients with cirrhosis. Transjugular intrahepatic portosystemic shunt (TIPS) has been reported to be an effective treatment of PVT in cirrhosis, with the advantage of avoiding the risk of bleeding linked to anticoagulation. In this study, we will evaluate the outcome of TIPS for PVT in patients with and without cirrhosis and determinate survival.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Written informed consent
- •Liver cirrosis or non-cirrhotic patients
- •Portal vein thrombosis (degree of vessel obstruction > 50%)
排除标准
- •Active variceal bleeding
- •Prior history of TIPS placement or shunt surgery
- •Concomitant renal insufficiency
- •Severe cardiopulmonary diseases
- •Uncontrolled sepsis Serious medical conditions which may reduce the life expectancy
- •Contraindications for TIPS
结局指标
主要结局
Outcome of TIPS for PVT in patients with and without cirrhosis
时间窗: 5 years
Clinical evolution after placement of TIPS
次要结局
未报告次要终点
研究者
ALDO TORRE DELGADILLO
MD
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran