Antibacterial efficacy of zinc oxide nanoparticle coated elastomeric modules- A Randomized Clinical trial
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 32
- Locations
- 1
- Primary Endpoint
- To evaluate
Study Overview
Brief Summary
Certain studies have evaluated the antibacterial efficacy of nanoparticle coated brackets and nanoparticle incorporated composite separately and studies have only evaluated the short term efficacy of nanoparticles on the cariogenic bacterial in the plaque. No studies have compared the efficacy of nanoparticle coated elastomeric modules over the uncoated modules. Long term studies are required to evaluate whether the efficacy of nanoparticles extends to reduced incidence of white spot lesions. Therefore, this study was designed to compare the efficacy of noanoparticles coated on elastomeric modules on long term against streptococcus mutans concentration in plaque and on the incidence of white spot lesions.
Study Design
- Study Type
- Interventional
- Allocation
- Other
- Masking
- None
Eligibility Criteria
- Ages
- 15.00 Year(s) to 30.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Patients undergoing orthodontic treatment Non- extraction fixed appliance cases Patients with good OHI.
- •Patients not taking medication Patients with no relevant medical history.
- •Patients with permanent dentition with full complement of teeth Patients with good gingival and periodontal health.
Exclusion Criteria
- •Patients with poor oral hygiene Patients with extensive dental caries Patients with no history of illness or allergies.
- •Patients with periodontitis and bone loss.
Outcomes
Primary Outcomes
To evaluate
Time Frame: End of 3 months and end of one year
streptococcus mutans concentration in plaque
Time Frame: End of 3 months and end of one year
using real-time
Time Frame: End of 3 months and end of one year
polymerase chain reaction (PCR) and white spot lesion formation
Time Frame: End of 3 months and end of one year
Secondary Outcomes
No secondary outcomes reported
Investigators
DrHemashree J
Sri Ramachandra Institute of Higher Education and Research